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Associations between absolute neutrophil count and lymphocyte-predominant breast cancer

DC FieldValueLanguage
dc.contributor.author신재일-
dc.date.accessioned2020-09-28T02:33:04Z-
dc.date.available2020-09-28T02:33:04Z-
dc.date.issued2020-04-
dc.identifier.issn0960-9776-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179097-
dc.description.abstractIntroduction: Tumor-infiltrating lymphocytes (TILs) might be associated with host-cell mediated immunity, which could be partly reflected by peripheral blood cell counts. In addition, lymphocyte-predominant breast cancer (LPBC), which was defined as tumors having high TIL levels, showed a favorable prognosis among triple-negative breast cancer or HER2-positive breast cancer. We aimed to investigate whether peripheral blood cell counts are associated with LPBC. Methods: We evaluated the percentage of stromal TILs in breast cancer patients who underwent primary surgery, using the standardized methodology proposed by the international TIL Working Group. Lymphocyte-predominant breast cancer (LPBC) was defined as tumors having high TIL levels (≥50%). Peripheral blood cell counts including absolute neutrophil counts (ANC), absolute lymphocyte counts (ALC) and neutrophil-to-lymphocyte ratio (NLR) was obtained from pretreatment laboratory data. Result: Of the 810 patients, 132 (16.3%) had LPBC, and 678 (83.7%) had non-LBPC. In a comparison of 3 markers of peripheral blood counts, LPBC had a significantly lower mean ANC than non-LPBC (3,304 vs. 3,564; P = 0.023), but the other means were not different. In multivariable analysis, each 1K increment in ANC corresponded to an odds ratio of 0.790 (95% CI, 0.642 to 0.971) for LPBC. In the ER-negative and high-Ki67 subgroups identified by interaction tests, significant inverse correlations between continuous ANC and TILs were noted. Conclusion: Low peripheral ANC could be linked with LPBC, supporting the hypothesis that systemic immune cell counts might be associated with the tumor-immune microenvironment.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfBREAST-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAssociations between absolute neutrophil count and lymphocyte-predominant breast cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.googleauthorChang Ik Yoon-
dc.contributor.googleauthorSoeun Park-
dc.contributor.googleauthorYoon Jin Cha-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorSoong June Bae-
dc.contributor.googleauthorChihwan Cha-
dc.contributor.googleauthorDa Young Lee-
dc.contributor.googleauthorSung Gwe Ahn-
dc.contributor.googleauthorJoon Jeong-
dc.identifier.doi10.1016/j.breast.2019.09.013-
dc.contributor.localIdA02142-
dc.relation.journalcodeJ00400-
dc.identifier.eissn1532-3080-
dc.identifier.pmid31607527-
dc.subject.keywordAbsolute neutrophil count-
dc.subject.keywordLymphocyte-predominant breast cancer-
dc.subject.keywordTIL-
dc.subject.keywordTumor-infiltrating lymphocyte-
dc.contributor.alternativeNameShin, Jae Il-
dc.contributor.affiliatedAuthor신재일-
dc.citation.volume50-
dc.citation.startPage141-
dc.citation.endPage148-
dc.identifier.bibliographicCitationBREAST, Vol.50 : 141-148, 2020-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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