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Distinctive Nanogels as high-efficiency Transdermal Carriers fot Skin Wound healing

Authors
 Seong Uk Son  ;  Soojin Jang  ;  Yuna Choi  ;  Mirae Park  ;  Hye Young Son  ;  Yong-Min Huh  ;  Soo-Jin Yeom  ;  Moon Sun Ham  ;  Do Kyung Lee  ;  Han-Na Kim  ;  Yeung-Bae Jin  ;  Taejoon Kang  ;  Juyeon Jung  ;  Eun-Kyung Lim 
Citation
 JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, Vol.16(3) : 304-314, 2020-03 
Journal Title
 JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 
ISSN
 1550-7033 
Issue Date
2020-03
MeSH
Administration, Cutaneous ; Drug Carriers ; Epidermal Growth Factor ; Nanogels* ; Skin ; Wound Healing*
Abstract
We propose that nanogels (HLGs) prepared by simply blending an epidermal growth factor (EGF)-loaded hyaluronan (HA)-based nanoformulation and poloxamers can be efficient transdermal drug carriers. In particular, due to the thermogelling behavior of poloxamer, when the HLGs, which are liquid at room temperature, are applied to the skin's surface, they form a gel at skin temperature. First, lipid-based nanoformulations (EGF-LNs) were fabricated by the lipid thin film method and then chemically conjugated with HA on the surface of the films to prepare EGF-loaded HA-based nanoformulations (EGF-HLNs). Both EGF-LNs and EGF-HLNs exhibited a uniform size and spherical lamellar structure. The EGF-HLN was added to a poloxamer solution to form EGF-HLG, which is a liquid at room temperature and a gel at skin temperature. HLGs have been shown to be able to deliver and permeate EGF well into the skin using both in vitro and in vivo systems, thus serving as an effective transdermal delivery system. In addition, it has been confirmed that this system could be a possible implantable drug carrier. Therefore, HLGs, which are uncomplicated and easily prepared, are expected to be easily used not only in the pharmaceutical field but also in the cosmetic field.
Full Text
https://www.ingentaconnect.com/content/asp/jbn/2020/00000016/00000003/art00003;jsessionid=jd52x9ag3hmk.x-ic-live-03
DOI
10.1166/jbn.2020.2893
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Son, Hye Yeong(손혜영) ORCID logo https://orcid.org/0000-0001-5977-6784
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179089
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