0 554

Cited 8 times in

The effect of interactions between proteinuria, activity of fibroblast growth factor 23 and serum phosphate on renal progression in patients with chronic kidney disease: a result from the KoreaN cohort study for Outcome in patients With Chronic Kidney Disease study

DC Field Value Language
dc.contributor.author윤해룡-
dc.contributor.author유태현-
dc.contributor.author박정탁-
dc.contributor.author남기헌-
dc.contributor.author강신욱-
dc.contributor.author지종현-
dc.contributor.author한승혁-
dc.contributor.author최규헌-
dc.date.accessioned2020-09-28T02:31:03Z-
dc.date.available2020-09-28T02:31:03Z-
dc.date.issued2020-03-
dc.identifier.issn0931-0509-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179084-
dc.description.abstractBackground: Recent experimental study reported that proteinuria increases serum phosphate by decreasing biologic activity of fibroblast growth factor 23 (FGF-23). We examined this relationship in a large chronic kidney disease (CKD) cohort and evaluated the combined effect of proteinuria, FGF-23 activity and serum phosphate on CKD progression. Methods: The activity of FGF-23, measured by the fractional excretion of phosphate (FEP)/FGF-23 ratio, was compared according to the degree of proteinuria in 1909 patients with CKD. Primary outcome was CKD progression defined as ≥50% decline of estimated glomerular filtration rate, doubling of serum creatinine and start of dialysis. Results: There was a negative relationship between 24-h urine protein (24-h UP) and FEP/FGF-23 ratio (γ -0.07; P = 0.005). In addition, after matching variables associated with serum phosphate, patients with more proteinuria had higher serum phosphate (P < 0.001) and FGF-23 (P = 0.012), and lower FEP/FGF-23 ratio (P = 0.007) compared with those with less proteinuria. In the matched cohort, low FEP/FGF-23 ratio was an independent risk factor for CKD progression (hazard ratio 0.87 per 1 log increase; 95% confidence interval 0.79-0.95; P = 0.002), and there was significant interaction between 24-h UP and FEP/FGF-23 ratio (P = 0.039). Furthermore, 24-h UP and serum phosphate also had a significant interaction on CKD progression (P < 0.001). Conclusions: Proteinuria is associated with decreased biologic activity of FGF-23 and increased serum phosphate. Furthermore, diminished activity of FGF23 is an independent risk factor for renal progression in proteinuric CKD patients.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherOxford University Press-
dc.relation.isPartOfNEPHROLOGY DIALYSIS TRANSPLANTATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleThe effect of interactions between proteinuria, activity of fibroblast growth factor 23 and serum phosphate on renal progression in patients with chronic kidney disease: a result from the KoreaN cohort study for Outcome in patients With Chronic Kidney Disease study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHyoungnae Kim-
dc.contributor.googleauthorJimin Park-
dc.contributor.googleauthorKi Heon Nam-
dc.contributor.googleauthorJong Hyun Jhee-
dc.contributor.googleauthorHae-Ryong Yun-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorWookyung Chung-
dc.contributor.googleauthorKook-Hwan Oh-
dc.contributor.googleauthorSue Kyung Park-
dc.contributor.googleauthorSoo Wan Kim-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorKyu Hun Choi-
dc.contributor.googleauthorCurie Ahn-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.identifier.doi10.1093/ndt/gfy403-
dc.contributor.localIdA04617-
dc.contributor.localIdA02526-
dc.contributor.localIdA01654-
dc.contributor.localIdA01244-
dc.contributor.localIdA00053-
dc.contributor.localIdA03970-
dc.contributor.localIdA04304-
dc.contributor.localIdA04043-
dc.relation.journalcodeJ02316-
dc.identifier.eissn1460-2385-
dc.identifier.pmid30615179-
dc.identifier.urlhttps://academic.oup.com/ndt/article/35/3/438/5273282-
dc.subject.keywordFGF-23-
dc.subject.keywordchronic kidney disease-
dc.subject.keywordphosphate-
dc.subject.keywordprognosis-
dc.subject.keywordproteinuria-
dc.contributor.alternativeNameYun, Hae Ryong-
dc.contributor.affiliatedAuthor윤해룡-
dc.contributor.affiliatedAuthor유태현-
dc.contributor.affiliatedAuthor박정탁-
dc.contributor.affiliatedAuthor남기헌-
dc.contributor.affiliatedAuthor강신욱-
dc.contributor.affiliatedAuthor지종현-
dc.contributor.affiliatedAuthor한승혁-
dc.contributor.affiliatedAuthor최규헌-
dc.citation.volume35-
dc.citation.number3-
dc.citation.startPage438-
dc.citation.endPage446-
dc.identifier.bibliographicCitationNEPHROLOGY DIALYSIS TRANSPLANTATION, Vol.35(3) : 438-446, 2020-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.