Cited 6 times in
Treatment outcome of anaplastic ependymoma under the age of 3 treated by intensity-modulated radiotherapy
DC Field | Value | Language |
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dc.contributor.author | 김동석 | - |
dc.contributor.author | 한정우 | - |
dc.contributor.author | 윤홍인 | - |
dc.contributor.author | 서창옥 | - |
dc.date.accessioned | 2020-09-28T02:07:48Z | - |
dc.date.available | 2020-09-28T02:07:48Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 2234-1900 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179055 | - |
dc.description.abstract | Purpose: Intensity-modulated radiotherapy (IMRT) allows for more precise treatment, reducing unwanted radiation to nearby structures. We investigated the safety and feasibility of IMRT for anaplastic ependymoma patients below 3 years of age. Materials and methods: A total of 9 anaplastic ependymoma patients below 3 years of age, who received IMRT between October 2011 and December 2017 were retrospectively reviewed. The median equivalent dose in 2 Gy fractions was 52.0 Gy (range, 48.0 to 60.0 Gy). Treatment outcomes and neurologic morbidities were reviewed in detail. Results: The median patient age was 20.9 months (range, 12.1 to 31.2 months). All patients underwent surgery. The rates of 5-year overall survival, freedom from local recurrence, and progression-free survival were 40.6%, 53.3%, and 26.7%, respectively. Of the 9 patients, 5 experienced recurrences (3 had local recurrence, 1 had both local recurrence and cerebrospinal fluid [CSF] seeding, and 1 had CSF seeding alone). Five patients died because of disease progression. Assessment of neurologic morbidity revealed motor dysfunction in 3 patients, all of whom presented with hydrocephalus at initial diagnosis because of the location of the tumor and already had neurologic deficits before radiotherapy (RT). Conclusion: Neurologic morbidity is not caused by RT alone but may result from mass effects of the tumor and surgical sequelae. Administration of IMRT to anaplastic ependymoma patients below 3 years of age yielded encouraging local control and tolerable morbidities. High-precision modern RT such as IMRT can be considered for very young patients with anaplastic ependymoma. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society for Therapeutic Radiology and Oncology | - |
dc.relation.isPartOf | RADIATION ONCOLOGY JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Treatment outcome of anaplastic ependymoma under the age of 3 treated by intensity-modulated radiotherapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학교실) | - |
dc.contributor.googleauthor | Joongyo Lee | - |
dc.contributor.googleauthor | Seung Yeun Chung | - |
dc.contributor.googleauthor | Jung Woo Han | - |
dc.contributor.googleauthor | Dong-Seok Kim | - |
dc.contributor.googleauthor | Jina Kim | - |
dc.contributor.googleauthor | Jin Young Moon | - |
dc.contributor.googleauthor | Hong In Yoon | - |
dc.contributor.googleauthor | Chang-Ok Suh | - |
dc.identifier.doi | 10.3857/roj.2020.00073 | - |
dc.contributor.localId | A00402 | - |
dc.contributor.localId | A04325 | - |
dc.contributor.localId | A04777 | - |
dc.contributor.localId | A01919 | - |
dc.relation.journalcode | J02592 | - |
dc.identifier.eissn | 2234-3164 | - |
dc.identifier.pmid | 32229806 | - |
dc.subject.keyword | Ependymoma | - |
dc.subject.keyword | Intensity-modulated radiotherapy | - |
dc.subject.keyword | Local neoplasm recurrence | - |
dc.subject.keyword | Morbidity | - |
dc.subject.keyword | Pediatrics | - |
dc.contributor.alternativeName | Kim, Dong Seok | - |
dc.contributor.affiliatedAuthor | 김동석 | - |
dc.contributor.affiliatedAuthor | 한정우 | - |
dc.contributor.affiliatedAuthor | 윤홍인 | - |
dc.contributor.affiliatedAuthor | 서창옥 | - |
dc.citation.volume | 38 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 26 | - |
dc.citation.endPage | 34 | - |
dc.identifier.bibliographicCitation | RADIATION ONCOLOGY JOURNAL, Vol.38(1) : 26-34, 2020-03 | - |
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