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Treatment outcome of anaplastic ependymoma under the age of 3 treated by intensity-modulated radiotherapy

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dc.contributor.author김동석-
dc.contributor.author한정우-
dc.contributor.author윤홍인-
dc.contributor.author서창옥-
dc.date.accessioned2020-09-28T02:07:48Z-
dc.date.available2020-09-28T02:07:48Z-
dc.date.issued2020-03-
dc.identifier.issn2234-1900-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179055-
dc.description.abstractPurpose: Intensity-modulated radiotherapy (IMRT) allows for more precise treatment, reducing unwanted radiation to nearby structures. We investigated the safety and feasibility of IMRT for anaplastic ependymoma patients below 3 years of age. Materials and methods: A total of 9 anaplastic ependymoma patients below 3 years of age, who received IMRT between October 2011 and December 2017 were retrospectively reviewed. The median equivalent dose in 2 Gy fractions was 52.0 Gy (range, 48.0 to 60.0 Gy). Treatment outcomes and neurologic morbidities were reviewed in detail. Results: The median patient age was 20.9 months (range, 12.1 to 31.2 months). All patients underwent surgery. The rates of 5-year overall survival, freedom from local recurrence, and progression-free survival were 40.6%, 53.3%, and 26.7%, respectively. Of the 9 patients, 5 experienced recurrences (3 had local recurrence, 1 had both local recurrence and cerebrospinal fluid [CSF] seeding, and 1 had CSF seeding alone). Five patients died because of disease progression. Assessment of neurologic morbidity revealed motor dysfunction in 3 patients, all of whom presented with hydrocephalus at initial diagnosis because of the location of the tumor and already had neurologic deficits before radiotherapy (RT). Conclusion: Neurologic morbidity is not caused by RT alone but may result from mass effects of the tumor and surgical sequelae. Administration of IMRT to anaplastic ependymoma patients below 3 years of age yielded encouraging local control and tolerable morbidities. High-precision modern RT such as IMRT can be considered for very young patients with anaplastic ependymoma.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society for Therapeutic Radiology and Oncology-
dc.relation.isPartOfRADIATION ONCOLOGY JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleTreatment outcome of anaplastic ependymoma under the age of 3 treated by intensity-modulated radiotherapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학교실)-
dc.contributor.googleauthorJoongyo Lee-
dc.contributor.googleauthorSeung Yeun Chung-
dc.contributor.googleauthorJung Woo Han-
dc.contributor.googleauthorDong-Seok Kim-
dc.contributor.googleauthorJina Kim-
dc.contributor.googleauthorJin Young Moon-
dc.contributor.googleauthorHong In Yoon-
dc.contributor.googleauthorChang-Ok Suh-
dc.identifier.doi10.3857/roj.2020.00073-
dc.contributor.localIdA00402-
dc.contributor.localIdA04325-
dc.contributor.localIdA04777-
dc.contributor.localIdA01919-
dc.relation.journalcodeJ02592-
dc.identifier.eissn2234-3164-
dc.identifier.pmid32229806-
dc.subject.keywordEpendymoma-
dc.subject.keywordIntensity-modulated radiotherapy-
dc.subject.keywordLocal neoplasm recurrence-
dc.subject.keywordMorbidity-
dc.subject.keywordPediatrics-
dc.contributor.alternativeNameKim, Dong Seok-
dc.contributor.affiliatedAuthor김동석-
dc.contributor.affiliatedAuthor한정우-
dc.contributor.affiliatedAuthor윤홍인-
dc.contributor.affiliatedAuthor서창옥-
dc.citation.volume38-
dc.citation.number1-
dc.citation.startPage26-
dc.citation.endPage34-
dc.identifier.bibliographicCitationRADIATION ONCOLOGY JOURNAL, Vol.38(1) : 26-34, 2020-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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