Cited 17 times in
Using comparative genomics to understand molecular features of carbapenem-resistant Acinetobacter baumannii from South Korea causing invasive infections and their clinical implications
DC Field | Value | Language |
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dc.contributor.author | 최준용 | - |
dc.contributor.author | 용동은 | - |
dc.date.accessioned | 2020-09-28T00:58:07Z | - |
dc.date.available | 2020-09-28T00:58:07Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179000 | - |
dc.description.abstract | Acinetobacter baumannii is a highly potent nosocomial pathogen that is associated with increased in-hospital mortality. Here, we investigated the changes in molecular characteristics of carbapenem-resistant A. baumannii (CRAB) isolated from the blood samples of patients admitted to a tertiary hospital in South Korea from January 2009 to July 2015. Whole genome sequencing using the Illumina MiSeq platform and multi-locus sequence typing (MLST) were performed for 98 CRAB clinical isolates. In silico analyses for the prediction of antimicrobial resistance and virulence factor genes were performed. Plasmid sequences, including complete forms, were reconstructed from the sequence reads. Epidemiologic data were collected from the hospital database. MLST using the Oxford scheme revealed 10 sequence types of CRAB, of which ST191 was the dominant type (n = 59). Although blaOXA-23 was shared by most analysed strains, the compositions of antimicrobial resistance determinants differed among sequence types. ST447 and ST451/ST1809 with a few resistance genes were isolated during the later years of the study period. The number of virulence genes increased, while that of ST191 did not change significantly over the investigation period. Intriguingly MLST types, compositions of antimicrobial resistance genes, and virulence genes had no association with clinical outcomes of CRAB bacteraemia. In conclusion, active changes in or accumulations of antimicrobial resistance determinants and virulence genes in CRAB were not observed during the research period. Molecular characteristics of CRAB had no association with clinical outcomes of CRAB bacteraemia. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Acinetobacter Infections / epidemiology | - |
dc.subject.MESH | Acinetobacter Infections / microbiology* | - |
dc.subject.MESH | Acinetobacter baumannii / drug effects | - |
dc.subject.MESH | Acinetobacter baumannii / genetics* | - |
dc.subject.MESH | Acinetobacter baumannii / isolation & purification | - |
dc.subject.MESH | Bacterial Proteins / genetics* | - |
dc.subject.MESH | Carbapenems / pharmacology* | - |
dc.subject.MESH | Cross Infection / epidemiology | - |
dc.subject.MESH | Cross Infection / microbiology* | - |
dc.subject.MESH | Drug Resistance, Bacterial / genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genomics / methods* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multilocus Sequence Typing | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Virulence Factors / genetics | - |
dc.title | Using comparative genomics to understand molecular features of carbapenem-resistant Acinetobacter baumannii from South Korea causing invasive infections and their clinical implications | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Min Hyung Kim | - |
dc.contributor.googleauthor | Haeyoung Jeong | - |
dc.contributor.googleauthor | Young Mi Sim | - |
dc.contributor.googleauthor | Soohyun Lee | - |
dc.contributor.googleauthor | Dongeun Yong | - |
dc.contributor.googleauthor | Choong-Min Ryu | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.identifier.doi | 10.1371/journal.pone.0229416 | - |
dc.contributor.localId | A04191 | - |
dc.contributor.localId | A02423 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 32084241 | - |
dc.contributor.alternativeName | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | 최준용 | - |
dc.contributor.affiliatedAuthor | 용동은 | - |
dc.citation.volume | 15 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | e0229416 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.15(2) : e0229416, 2020-02 | - |
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