Cited 8 times in
Enzalutamide in chemotherapy-naive patients with metastatic castration-resistant prostate cancer: A retrospective Korean multicenter study in a real-world setting
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이승환 | - |
dc.contributor.author | 정병하 | - |
dc.date.accessioned | 2020-09-28T00:53:36Z | - |
dc.date.available | 2020-09-28T00:53:36Z | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 2466-0493 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/178976 | - |
dc.description.abstract | Purpose: This study aimed to evaluate the clinical efficacy of enzalutamide in chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC) patients using real-world data from Korean patients. Materials and methods: We retrospectively reviewed the medical records of 199 chemotherapy-naïve patients with mCRPC at 13 tertiary centers in Korea between 2014 and 2017. All patients received enzalutamide daily and 89 patients received concurrent androgen deprivation therapy (ADT). Results: The median age of the patients was 74 years. Initial results showed that 81.5% of the patients had Gleason score ≥8 and 33.3% of the patients had European Cooperative Oncology Group Performance Status 0. The overall mortality rate was 12%. The median OS was not archieved and 76.7% of patients were alive at 30 months. Median time until PSA progression was 6 months. The overall survival rate at 2 years was significantly higher (84.6% vs. 71.7%, p=0.015) and the duration of PSA progression-free survival was significantly longer (8.0 vs. 4.6 months, p=0.008) in patients receiving concurrent ADT than in those receiving enzalutamide alone. The incidence of adverse events of grade 3 or higher was 1.7%. Multivariate Cox proportional hazard analysis indicated that ADT administered concurrently with enzalutamide significantly improved the overall survival (hazard ratio, 0.346; 95% confidence interval, 0.125-0.958). Conclusions: Enzalutamide is effective and safe for chemotherapy-naïve patients with mCRPC. Furthermore, the overall survival was significantly higher in patients receiving enzalutamide and concurrent ADT than in patients receiving enzalutamide alone. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Korean Urological Association | - |
dc.relation.isPartOf | INVESTIGATIVE AND CLINICAL UROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Enzalutamide in chemotherapy-naive patients with metastatic castration-resistant prostate cancer: A retrospective Korean multicenter study in a real-world setting | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | Seung Il Jung | - |
dc.contributor.googleauthor | Myung Soo Kim | - |
dc.contributor.googleauthor | Chang Wook Jeong | - |
dc.contributor.googleauthor | Cheol Kwak | - |
dc.contributor.googleauthor | Sung Kyu Hong | - |
dc.contributor.googleauthor | Seok Ho Kang | - |
dc.contributor.googleauthor | Jae Young Joung | - |
dc.contributor.googleauthor | Seung Hwan Lee | - |
dc.contributor.googleauthor | Seok Joong Yun | - |
dc.contributor.googleauthor | Tae-Hwan Kim | - |
dc.contributor.googleauthor | Sung Woo Park | - |
dc.contributor.googleauthor | Seong Soo Jeon | - |
dc.contributor.googleauthor | Minyong Kang | - |
dc.contributor.googleauthor | Ji Youl Lee | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.contributor.googleauthor | Jun Hyuk Hong | - |
dc.contributor.googleauthor | Hanjong Ahn | - |
dc.contributor.googleauthor | Choung-Soo Kim | - |
dc.contributor.googleauthor | Dong Deuk Kwon | - |
dc.identifier.doi | 10.4111/icu.2020.61.1.19 | - |
dc.contributor.localId | A02938 | - |
dc.contributor.localId | A03607 | - |
dc.relation.journalcode | J01185 | - |
dc.identifier.eissn | 2466-054X | - |
dc.identifier.pmid | 31942459 | - |
dc.subject.keyword | Androgen antagonists | - |
dc.subject.keyword | Neoplasm metastasis | - |
dc.subject.keyword | Prostate neoplasms | - |
dc.subject.keyword | Treatment outcome | - |
dc.contributor.alternativeName | Lee, Seung Hwan | - |
dc.contributor.affiliatedAuthor | 이승환 | - |
dc.contributor.affiliatedAuthor | 정병하 | - |
dc.citation.volume | 61 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 19 | - |
dc.citation.endPage | 27 | - |
dc.identifier.bibliographicCitation | INVESTIGATIVE AND CLINICAL UROLOGY, Vol.61(1) : 19-27, 2020-01 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.