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Randomized, Double-Blind, Placebo-Controlled Trial on the Efficacy of Hyaluronidase in Preventing Perineal Trauma in Nulliparous Women

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dc.contributor.author권하얀-
dc.date.accessioned2020-09-28T00:52:54Z-
dc.date.available2020-09-28T00:52:54Z-
dc.date.issued2020-01-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/178972-
dc.description.abstractPurpose: Hyaluronidase (HAase) has many uses in medicine, and reports suggest that it affects perineal tissue during fetal passage through the vaginal canal. However, its potential use for preventing perineal trauma has yet to be determined. This study sought to evaluate the efficacy and safety of perineal HAase injections in reducing perineal trauma during vaginal delivery. Materials and methods: A multi-center, double-blind, placebo-controlled, randomized study was conducted from January 2016 to March 2017. Nulliparous women who planned to undergo vaginal delivery were recruited, and the enrolled women were randomly assigned to the HAase injection group (HAase injection, 5000 IU, n=75) or the control group (normal saline injection, n=73). The degree of perineal laceration, rate of episiotomy, and grade of perineal edema at 1 hour and 24 hours after spontaneous vaginal delivery were compared between the two groups. Results: A total of 148 women who underwent vaginal delivery were recruited. No significant differences were observed between the HAase injection and control groups in the rates of perineal laceration (p=0.422). Perineal edema significantly decreased 24 hours after delivery in the women treated with perineal HAase injections, compared to women in the control group (p=0.008). The overall incidences of adverse events, such as redness of the injection site, infection, and wound dehiscence, were similar between the two groups. Conclusion: HAase injections in nulliparous women afforded no reductions in the rates of perineal lacerations and episiotomy. However, the use of perineal HAase injections did reduce perineal edema without severe adverse events.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHDelivery, Obstetric-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHEdema / pathology-
dc.subject.MESHEpisiotomy-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHyaluronoglucosaminidase / administration & dosage-
dc.subject.MESHHyaluronoglucosaminidase / therapeutic use*-
dc.subject.MESHIncidence-
dc.subject.MESHInfant, Newborn-
dc.subject.MESHLacerations / etiology-
dc.subject.MESHPerineum / pathology*-
dc.subject.MESHPlacebos-
dc.subject.MESHPregnancy-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHWounds and Injuries / drug therapy*-
dc.subject.MESHYoung Adult-
dc.titleRandomized, Double-Blind, Placebo-Controlled Trial on the Efficacy of Hyaluronidase in Preventing Perineal Trauma in Nulliparous Women-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.googleauthorHayan Kwon-
dc.contributor.googleauthorHyun Soo Park-
dc.contributor.googleauthorJae Yoon Shim-
dc.contributor.googleauthorKyo Won Lee-
dc.contributor.googleauthorSuk Joo Choi-
dc.contributor.googleauthorGyu Yeon Choi-
dc.identifier.doi10.3349/ymj.2020.61.1.79-
dc.contributor.localIdA00257-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid31887803-
dc.subject.keywordVaginal delivery-
dc.subject.keywordhyaluronidase-
dc.subject.keywordnulliparity-
dc.subject.keywordperineal trauma-
dc.subject.keywordrandomized controlled trial-
dc.contributor.alternativeNameKwon, Ha Yan-
dc.contributor.affiliatedAuthor권하얀-
dc.citation.volume61-
dc.citation.number1-
dc.citation.startPage79-
dc.citation.endPage84-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.61(1) : 79-84, 2020-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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