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The incidence rates and risk factors of Parkinson disease in patients with psoriasis: A nationwide population-based cohort study

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dc.contributor.author지헌영-
dc.date.accessioned2020-09-07T06:51:21Z-
dc.date.available2020-09-07T06:51:21Z-
dc.date.issued2019-07-
dc.identifier.issn0190-9622-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/178934-
dc.description.abstractBackground: The association between psoriasis and Parkinson disease has not been established. Objective: To determine the incidence rates and risk factors of Parkinson disease in patients with psoriasis. Methods: We conducted a nationwide population-based cohort study. The data from patients with psoriasis (N = 548,327, ≥20 years of age, 53.32% men and 46.68% women) and age- and sex-matched control patients (N = 2,741,635) without psoriasis were analyzed in this study. Results: The incidence rates of Parkinson disease per 1000 person-years were 0.673 and 0.768 in the control and psoriasis groups, respectively. The psoriasis group showed a significantly increased risk of developing Parkinson disease (hazard ratio [HR] 1.091, 95% confidence interval [CI] 1.029-1.115). The risk of Parkinson disease was significantly higher among the psoriasis patients who were not receiving systemic therapy (HR 1.093, 95% CI 1.031-1.159) and lower among the psoriasis patients on systemic therapy (HR 1.04, 95% CI 0.806-1.316). Limitations: The limitations of this study included the retrospective design, patient inclusion solely on the basis of diagnostic codes, and unavailability of data on confounding factors. Conclusion: Systemic anti-inflammatory agents might mitigate the risk of Parkinson disease in psoriasis patients.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherMosby-
dc.relation.isPartOfJOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleThe incidence rates and risk factors of Parkinson disease in patients with psoriasis: A nationwide population-based cohort study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학교실)-
dc.contributor.googleauthorJi Hyun Lee-
dc.contributor.googleauthorKyungdo Han-
dc.contributor.googleauthorHeon Yung Gee-
dc.identifier.doi10.1016/j.jaad.2019.07.012-
dc.contributor.localIdA03971-
dc.relation.journalcodeJ01766-
dc.identifier.eissn1097-6787-
dc.identifier.pmid31302182-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0190962219323679-
dc.subject.keywordParkinson disease-
dc.subject.keywordcohort study-
dc.subject.keywordincidence-
dc.subject.keywordpopulation-based-
dc.subject.keywordpsoriasis-
dc.subject.keywordrisk factor-
dc.contributor.alternativeNameGee, Heon Yung-
dc.contributor.affiliatedAuthor지헌영-
dc.citation.startPageepub.-
dc.identifier.bibliographicCitationJOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, : epub., 2019-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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