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The incidence rates and risk factors of Parkinson disease in patients with psoriasis: A nationwide population-based cohort study

Authors
 Ji Hyun Lee  ;  Kyungdo Han  ;  Heon Yung Gee 
Citation
 JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, : epub., 2019-07 
Journal Title
 JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 
ISSN
 0190-9622 
Issue Date
2019-07
Keywords
Parkinson disease ; cohort study ; incidence ; population-based ; psoriasis ; risk factor
Abstract
Background: The association between psoriasis and Parkinson disease has not been established. Objective: To determine the incidence rates and risk factors of Parkinson disease in patients with psoriasis. Methods: We conducted a nationwide population-based cohort study. The data from patients with psoriasis (N = 548,327, ≥20 years of age, 53.32% men and 46.68% women) and age- and sex-matched control patients (N = 2,741,635) without psoriasis were analyzed in this study. Results: The incidence rates of Parkinson disease per 1000 person-years were 0.673 and 0.768 in the control and psoriasis groups, respectively. The psoriasis group showed a significantly increased risk of developing Parkinson disease (hazard ratio [HR] 1.091, 95% confidence interval [CI] 1.029-1.115). The risk of Parkinson disease was significantly higher among the psoriasis patients who were not receiving systemic therapy (HR 1.093, 95% CI 1.031-1.159) and lower among the psoriasis patients on systemic therapy (HR 1.04, 95% CI 0.806-1.316). Limitations: The limitations of this study included the retrospective design, patient inclusion solely on the basis of diagnostic codes, and unavailability of data on confounding factors. Conclusion: Systemic anti-inflammatory agents might mitigate the risk of Parkinson disease in psoriasis patients.
Full Text
https://www.sciencedirect.com/science/article/pii/S0190962219323679
DOI
10.1016/j.jaad.2019.07.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Gee, Heon Yung(지헌영) ORCID logo https://orcid.org/0000-0002-8741-6177
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178934
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