Cited 113 times in
NK and NK-like T-cell lymphoma in extranasal sites: a comparative clinicopathological study according to site and EBV status
DC Field | Value | Language |
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dc.contributor.author | 양우익 | - |
dc.date.accessioned | 2020-09-04T02:13:00Z | - |
dc.date.available | 2020-09-04T02:13:00Z | - |
dc.date.issued | 2004-05 | - |
dc.identifier.issn | 0309-0167 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/178876 | - |
dc.description.abstract | Aims: To analyse the clinicopathological findings of extranasal CD56+ cytotoxic T- or NK-cell lymphomas in different organs and to compare Epstein-Barr virus (EBV)+ and EBV- lymphoma of non-blastoid cytomorphology. Methods and results: Fifty-one cases of cCD3+ T-cell intracellular antigen (TIA-1)+ CD56+ lymphomas of extranodal/extranasal origin were included in the study. The primary sites of the CD56+ tumours were soft tissue (n = 10), the gastrointestinal (GI) tract (n = 13), the skin (n = 15), upper aerodigestive tract excluding nasal and nasopharyngeal regions (n = 11), the testis (n = 1), and parotid gland (n = 1). TCR gene rearrangement was detected in seven of 47 cases examined (16%). EBV was positive in 39 of 51 cases (76%). The positive rate of EBV was higher in tumours of soft tissue (80%), GI tract (92%), and skin (80%), and lowest in the upper aerodigestive tract excluding the nasal and nasopharyngeal region (50%). Tumours of the soft tissue and the upper aerodigestive tract tended to present with localized disease (P = 0.002). The 2-year survival rate was lowest for tumours of the GI tract (P = 0.0256). EBV- TCR- lymphoma showed less necrosis (P = 0.0133) and a better 2-year survival rate (P = 0.0066) than EBV+ TCR- lymphoma. Patients with EBV+ TCR+ lymphomas tended to present with localized disease, more often than EBV+ TCR- lymphoma (P = 0.0186). Significant prognostic factors in all CD56+ lymphomas were the site (P = 0.0256), EBV status (P = 0.0026), necrosis with or without perforation (P = 0.0338) and the presence of pleomorphic large tumour cells (P = 0.0428). Cox's regression analysis adjusting for other pathological parameters showed EBV status to be the only independent prognostic factor (P = 0.018). Conclusions: Extranodal CD56+ EBV- lymphoma at extranasal sites is a clinically less aggressive malignancy and displays less necrosis than CD56+ EBV+ lymphoma. Because CD56+ EBV+ TCR+ lymphomas show similar pathological and clinical findings to CD56+ EBV+ TCR- lymphomas, nasal-type NK/T-cell lymphomas at extranasal sites should be diagnosed as such on the basis of EBV+, cytotoxic T or NK phenotype irrespective of the genotype determined by molecular study. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Blackwell Scientific Publications | - |
dc.relation.isPartOf | HISTOPATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | CD56 Antigen / metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gastrointestinal Neoplasms / genetics | - |
dc.subject.MESH | Gastrointestinal Neoplasms / pathology | - |
dc.subject.MESH | Gastrointestinal Neoplasms / virology | - |
dc.subject.MESH | Gene Rearrangement | - |
dc.subject.MESH | Head and Neck Neoplasms / genetics | - |
dc.subject.MESH | Head and Neck Neoplasms / pathology | - |
dc.subject.MESH | Head and Neck Neoplasms / virology | - |
dc.subject.MESH | Herpesvirus 4, Human / isolation & purification* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Situ Hybridization | - |
dc.subject.MESH | Killer Cells, Natural* | - |
dc.subject.MESH | Lymphoma, T-Cell, Peripheral / diagnosis | - |
dc.subject.MESH | Lymphoma, T-Cell, Peripheral / genetics | - |
dc.subject.MESH | Lymphoma, T-Cell, Peripheral / metabolism | - |
dc.subject.MESH | Lymphoma, T-Cell, Peripheral / mortality | - |
dc.subject.MESH | Lymphoma, T-Cell, Peripheral / pathology* | - |
dc.subject.MESH | Lymphoma, T-Cell, Peripheral / virology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Necrosis / pathology | - |
dc.subject.MESH | Parotid Neoplasms / genetics | - |
dc.subject.MESH | Parotid Neoplasms / pathology | - |
dc.subject.MESH | Parotid Neoplasms / virology | - |
dc.subject.MESH | Poly(A)-Binding Proteins | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proteins / metabolism | - |
dc.subject.MESH | RNA, Viral / analysis | - |
dc.subject.MESH | RNA-Binding Proteins | - |
dc.subject.MESH | Soft Tissue Neoplasms / genetics | - |
dc.subject.MESH | Soft Tissue Neoplasms / pathology | - |
dc.subject.MESH | Soft Tissue Neoplasms / virology | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | T-Cell Intracellular Antigen-1 | - |
dc.subject.MESH | Testicular Neoplasms / genetics | - |
dc.subject.MESH | Testicular Neoplasms / pathology | - |
dc.subject.MESH | Testicular Neoplasms / virology | - |
dc.title | NK and NK-like T-cell lymphoma in extranasal sites: a comparative clinicopathological study according to site and EBV status | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Y H Ko | - |
dc.contributor.googleauthor | E-Y Cho | - |
dc.contributor.googleauthor | J-E Kim | - |
dc.contributor.googleauthor | S-S Lee | - |
dc.contributor.googleauthor | J-R Huh | - |
dc.contributor.googleauthor | H-K Chang | - |
dc.contributor.googleauthor | W-I Yang | - |
dc.contributor.googleauthor | C-W Kim | - |
dc.contributor.googleauthor | S-W Kim | - |
dc.contributor.googleauthor | H J Ree | - |
dc.identifier.doi | 10.1111/j.1365-2559.2004.01867.x | - |
dc.contributor.localId | A02300 | - |
dc.relation.journalcode | J00994 | - |
dc.identifier.eissn | 1365-2559 | - |
dc.identifier.pmid | 15139996 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2559.2004.01867.x | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | 양우익 | - |
dc.citation.volume | 44 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 480 | - |
dc.citation.endPage | 489 | - |
dc.identifier.bibliographicCitation | HISTOPATHOLOGY, Vol.44(5) : 480-489, 2004-05 | - |
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