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Effect of ipsilateral subthalamic nucleus lesioning in a rat parkinsonian model: study of behavior correlated with neuronal activity in the pedunculopontine nucleus
DC Field | Value | Language |
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dc.contributor.author | 박용구 | - |
dc.contributor.author | 이배환 | - |
dc.contributor.author | 장진우 | - |
dc.date.accessioned | 2020-09-04T02:11:50Z | - |
dc.date.available | 2020-09-04T02:11:50Z | - |
dc.date.issued | 2003-10 | - |
dc.identifier.issn | 0022-3085 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/178865 | - |
dc.description.abstract | Object: The purpose of this study was to investigate the spontaneous behavioral changes and the alteration of neuronal activities in the pedunculopontine nucleus (PPN) after ipsilateral subthalamic nucleus (STN) lesioning by kainic acid in a rat parkinsonian model created by lesioning with 6-hydroxydopamine (6-OHDA). Methods: Assumptions about the mechanisms mediating the effects of lesioning of the nigrostriatal dopaminergic pathway by 6-OHDA and the effects of STN lesioning were examined behaviorally by means of apomorphine-induced rotational behavior and forepaw-adjusting steps. The authors subsequently investigated the alteration of neuronal activities in the PPN to compare them with the behavioral changes in rat parkinsonian models. Conclusions: The results demonstrated that STN lesioning induced behavioral improvement in rat parkinsonian models. This result, which confirms previously held assumptions, may account for the therapeutic effect of STN stimulation in Parkinson disease. The alteration of the neuronal activities in the PPN units also indicates that the PPN units are responsible for the improvement in motor symptoms observed after STN lesioning in rat parkinsonian models. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Association of Neurological Surgeons | - |
dc.relation.isPartOf | JOURNAL OF NEUROSURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adrenergic Agents / administration & dosage | - |
dc.subject.MESH | Adrenergic Agents / adverse effects | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Basal Ganglia / drug effects | - |
dc.subject.MESH | Behavior, Animal / drug effects | - |
dc.subject.MESH | Corpus Striatum / physiopathology | - |
dc.subject.MESH | Excitatory Amino Acid Agonists / administration & dosage | - |
dc.subject.MESH | Excitatory Amino Acid Agonists / adverse effects | - |
dc.subject.MESH | Functional Laterality / physiology | - |
dc.subject.MESH | Kainic Acid / administration & dosage | - |
dc.subject.MESH | Kainic Acid / adverse effects | - |
dc.subject.MESH | Locomotion / drug effects | - |
dc.subject.MESH | Mesencephalon / drug effects* | - |
dc.subject.MESH | Neurons / drug effects* | - |
dc.subject.MESH | Oxidopamine / administration & dosage | - |
dc.subject.MESH | Oxidopamine / adverse effects | - |
dc.subject.MESH | Parkinsonian Disorders / chemically induced | - |
dc.subject.MESH | Parkinsonian Disorders / physiopathology* | - |
dc.subject.MESH | Pons / drug effects* | - |
dc.subject.MESH | Pons / physiopathology* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Rotation | - |
dc.subject.MESH | Substantia Nigra / physiopathology | - |
dc.subject.MESH | Subthalamic Nucleus / physiopathology* | - |
dc.title | Effect of ipsilateral subthalamic nucleus lesioning in a rat parkinsonian model: study of behavior correlated with neuronal activity in the pedunculopontine nucleus | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학교실) | - |
dc.contributor.googleauthor | Mi Fa Jeon | - |
dc.contributor.googleauthor | Yoon Ha | - |
dc.contributor.googleauthor | Yoon Hee Cho | - |
dc.contributor.googleauthor | Bae Hwan Lee | - |
dc.contributor.googleauthor | Yong Gou Park | - |
dc.contributor.googleauthor | Jin Woo Chang | - |
dc.identifier.doi | 10.3171/jns.2003.99.4.0762 | - |
dc.contributor.localId | A01578 | - |
dc.contributor.localId | A02791 | - |
dc.contributor.localId | A03484 | - |
dc.relation.journalcode | J01636 | - |
dc.identifier.eissn | 1933-0693 | - |
dc.identifier.pmid | 14567613 | - |
dc.identifier.url | https://thejns.org/view/journals/j-neurosurg/99/4/article-p762.xml | - |
dc.contributor.alternativeName | Park, Yong Gou | - |
dc.contributor.affiliatedAuthor | 박용구 | - |
dc.contributor.affiliatedAuthor | 이배환 | - |
dc.contributor.affiliatedAuthor | 장진우 | - |
dc.citation.volume | 99 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 762 | - |
dc.citation.endPage | 767 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROSURGERY, Vol.99(4) : 762-767, 2003-10 | - |
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