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Role of peroxisome proliferator-activated receptor-gamma in the glucose-sensing apparatus of liver and beta-cells

Authors
 Ha-Il Kim  ;  Yong-Ho Ahn 
Citation
 DIABETES, Vol.53(Suppl 1) : S60-S65, 2004-02 
Journal Title
 DIABETES 
ISSN
 0012-1797 
Issue Date
2004-02
MeSH
Animals ; Glucose / physiology* ; Humans ; Insulin / metabolism* ; Insulin Secretion ; Islets of Langerhans / physiology* ; Liver / physiology* ; Mice ; Models, Biological ; Rats ; Receptors, Cytoplasmic and Nuclear / physiology* ; Transcription Factors / physiology*
Abstract
Type 2 diabetes develops in the context of both insulin resistance and beta-cell failure. Thiazolidinediones are a class of antidiabetic agents that are known to improve insulin sensitivity in various animal models of diabetes. The improved insulin sensitivity may be achieved either by systemic insulin sensitization or by direct action of peroxisome proliferator-activated receptor (PPAR)-gamma on the transcription of genes involved in glucose disposal. Evidence supporting the direct action of PPAR-gamma on glucose metabolism is observed in the genes involved in insulin-stimulated glucose disposal. We already showed that GLUT2 and beta-glucokinase were directly activated by PPAR-gamma. Recently, we have identified and characterized the functional PPAR response element in the GLUT2 and liver type glucokinase (LGK) promoter of the liver. It is well known that adipose tissue plays a crucial role in antidiabetic action of PPAR-gamma. In addition, PPAR-gamma can directly affect liver and pancreatic beta-cells to improve glucose homeostasis.
Files in This Item:
T200404986.pdf Download
DOI
10.2337/diabetes.53.2007.s60
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Yong Ho(안용호) ORCID logo https://orcid.org/0000-0002-4133-0757
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178836
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