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Retinoic acid receptor-beta expression in stage I non-small cell lung cancer and adjacent normal appearing bronchial epithelium

 Yoon Soo Chang  ;  Jae Ho Chung  ;  Dong Hwan Shin  ;  Kyung Young Chung  ;  Young Sam Kim  ;  Joon Chang  ;  Sung Kyu Kim  ;  Se Kyu Kim 
 YONSEI MEDICAL JOURNAL, Vol.45(3) : 435-442, 2004-06 
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Adult ; Aged ; Biomarkers, Tumor / metabolism* ; Bronchi / metabolism ; Bronchi / pathology ; Carcinoma, Non-Small-Cell Lung / metabolism* ; Carcinoma, Non-Small-Cell Lung / pathology ; Down-Regulation ; Female ; Humans ; Immunohistochemistry ; Lung Neoplasms / metabolism* ; Lung Neoplasms / pathology ; Male ; Middle Aged ; Neoplasm Staging ; Receptors, Retinoic Acid / metabolism* ; Respiratory Mucosa / pathology*
Retinoic acid receptor-beta (RAR-beta) is induced by and mediates the growth-inhibitory and apoptotic effects of retinoic acid (RA), suggesting that loss of RAR-beta expression may be one of the critical events involved in the carcinogenesis/ progression of non-small cell lung cancer (NSCLC) and in the responsiveness to retinoid chemotherapy. However, recent contradictory reports that the expression of RAR-beta is associated with poor clinical outcome, and the fact that treatment of serum-deprived type 2 alveolar cells with RA leads to a stimulation of cell proliferation, require the verification of RAR-beta as a biomarker of chemoprevention or prognosis. The expression status of RAR-beta in cancer cells and adjacent normal appearing bronchial epithelium from 39 patients, diagnosed as stage I NSCLC and undergone a curative lung resection, was analyzed in paraffin-embedded tissue sections by IHC staining. The normal appearing bronchial epithelium of 14 out of 33 (42.4%) specimens expressed RAR-beta, whereas 22 out of the 39 (56.4%) stage I NSCLC specimens expressed RAR-beta. RAR-beta was more frequently expressed in the adenocarcinoma (72.7%) than in the squamous cell carcinoma (31.3%) (p=0.026). Neither the expression status in normal appearing adjacent tissue nor that in the tumor tissue had prognostic implications. The higher expression of RAR-beta in cancer tissue, the focal and uneven distribution in normal appearing adjacent bronchial epithelium, and inconsistency with the corresponding tumor tissue, suggest that the expression status of RAR-beta as a biomarker for chemoprevention/early diagnosis or the prognosis of NSCLC requires further consideration.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
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Chang, Yoon Soo(장윤수) ORCID logo https://orcid.org/0000-0003-3340-4223
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