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Fine needle aspiration cytology of small cell variant of anaplastic large cell lymphoma. A case report

Authors
 Sung-Eun Kim  ;  Se Hoon Kim  ;  Beom Jin Lim  ;  Soon-Won Hong  ;  Woo-Ick Yang 
Citation
 ACTA CYTOLOGICA, Vol.48(2) : 254-258, 2004-03 
Journal Title
 ACTA CYTOLOGICA 
ISSN
 0001-5547 
Issue Date
2004-03
MeSH
Adolescent ; Anaplastic Lymphoma Kinase ; Biomarkers, Tumor / metabolism* ; Cell Lineage / genetics ; Female ; Humans ; Immunohistochemistry ; Immunophenotyping ; Ki-1 Antigen / metabolism ; Lymph Nodes / pathology* ; Lymphocytes / metabolism ; Lymphocytes / pathology* ; Lymphoma, Large B-Cell, Diffuse / pathology* ; Predictive Value of Tests ; Protein-Tyrosine Kinases / metabolism ; Receptor Protein-Tyrosine Kinases ; Reproducibility of Results ; Skin Neoplasms / secondary*
Abstract
Background: Small cell variant of anaplastic large cell lymphoma (ALCL) is a rare and still underrecognized variant of ALCL. In contrast to the classic type of ALCL, which is sometimes mistaken for carcinoma or sarcoma, the small cell variant may be misdiagnosed as a reactive lesion without a high index of suspicion. Case: We present a case of small cell variant of ALCL occurring in a 14-year-old female. It posed great difficulty in the fine needle aspiration (FNA) diagnosis due to the rarity of large, atypical cells. A subsequent lymph node biopsy demonstrated the typical histologic and immunophenotypic findings of the small cell variant of ALCL. Conclusion: This case indicates that small cell variant of ALCL should always be considered in the FNA diagnosis of unusual-looking, heterogeneous lymphoid proliferations dominated by atypical small or medium-sized lymphoid cells, particularly in young patients.
Full Text
https://www.karger.com/Article/Abstract/326327
DOI
10.1159/000326327
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178804
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