Cited 22 times in
Dominant negative insulin-like growth factor-1 receptor inhibits neointimal formation through suppression of vascular smooth muscle cell migration and proliferation, and induction of apoptosis
DC Field | Value | Language |
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dc.contributor.author | 고영국 | - |
dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2020-09-04T02:05:47Z | - |
dc.date.available | 2020-09-04T02:05:47Z | - |
dc.date.issued | 2004-12 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/178802 | - |
dc.description.abstract | Blocking of the IGF-1 signaling pathway targeting the IGF-1 receptor (IGF-1R) provides a potential treatment strategy for restenosis. In this study, we have examined the effects of a dominant negative IGF-1R (IGF-1Rt) on primary rat VSMCs in vitro and on injured rat carotid artery in vivo. Ad/IGF-1Rt infection inhibited VSMC migration and proliferation, and it also induced apoptosis by inhibiting phosphorylation of Akt and phosphorylation of ERK1/2. Consistent with the anti-proliferative and apoptotic effects in vitro, the Ad/IGF-1Rt infection markedly reduced neointimal formation in carotid injury model. Ad/IGF-1Rt treated carotid arteries exhibited a suppressed proliferation index, PCNA expression, and also were stained positive for TUNEL assay. These results indicate that a dominant negative IGF-1R has the potential to reduce neointimal formation of injured rats' carotid arteries. The delivery of dominant negative IGF-1R by adenoviral or other vectors may provide a useful strategy for inhibiting restenosis after angioplasty. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Angioplasty, Balloon / adverse effects | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis / drug effects | - |
dc.subject.MESH | Apoptosis / genetics | - |
dc.subject.MESH | Cell Movement / drug effects | - |
dc.subject.MESH | Cell Movement / genetics | - |
dc.subject.MESH | Cell Proliferation / drug effects | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Coronary Restenosis / etiology | - |
dc.subject.MESH | Coronary Restenosis / genetics | - |
dc.subject.MESH | Coronary Restenosis / pathology* | - |
dc.subject.MESH | Coronary Restenosis / prevention & control* | - |
dc.subject.MESH | Gene Transfer Techniques* | - |
dc.subject.MESH | Genes, Dominant / genetics | - |
dc.subject.MESH | Genetic Therapy / methods | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Muscle, Smooth, Vascular / drug effects | - |
dc.subject.MESH | Muscle, Smooth, Vascular / physiopathology* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Receptor, IGF Type 1 / agonists* | - |
dc.subject.MESH | Receptor, IGF Type 1 / genetics* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Tunica Intima / drug effects | - |
dc.subject.MESH | Tunica Intima / growth & development | - |
dc.subject.MESH | Tunica Intima / pathology | - |
dc.title | Dominant negative insulin-like growth factor-1 receptor inhibits neointimal formation through suppression of vascular smooth muscle cell migration and proliferation, and induction of apoptosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hyun-Joung Lim 1 , Hyun-Young Park, Young-Guk Ko, Sea-Hyoung Lee, Seung-Yeon Cho, Eun Jig Lee, J Larry Jameson, Yangsoo Jang | - |
dc.identifier.doi | 10.1016/j.bbrc.2004.10.175 | - |
dc.contributor.localId | A00127 | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 15541402 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0006291X04024234 | - |
dc.contributor.alternativeName | Ko, Young Guk | - |
dc.contributor.affiliatedAuthor | 고영국 | - |
dc.contributor.affiliatedAuthor | 장양수 | - |
dc.citation.volume | 325 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1106 | - |
dc.citation.endPage | 1114 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.325(3) : 1106-1114, 2004-12 | - |
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