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Developmental properties of the Hertwig's epithelial root sheath in mice

Authors
 H Yamamoto  ;  S-W Cho  ;  E-J Kim  ;  J-Y Kim  ;  N Fujiwara  ;  H-S Jung 
Citation
 JOURNAL OF DENTAL RESEARCH, Vol.83(9) : 688-692, 2004-01 
Journal Title
 JOURNAL OF DENTAL RESEARCH 
ISSN
 0022-0345 
Issue Date
2004-01
MeSH
Animals ; Bone Morphogenetic Protein 2 ; Bone Morphogenetic Protein 4 ; Bone Morphogenetic Proteins / analysis ; Cell Adhesion ; Cell Death ; Cell Division ; Cell Movement ; Culture Techniques ; DNA-Binding Proteins / analysis ; Enamel Organ / growth & development* ; Epithelium / growth & development ; Glycoproteins / analysis ; Homeodomain Proteins / analysis ; Laminin / analysis ; Membrane Glycoproteins / analysis ; Mice ; Mice, Inbred ICR ; Morphogenesis / physiology ; Odontogenesis / physiology* ; Proteoglycans / analysis ; Syndecan-1 ; Syndecans ; Tooth Root / growth & development* ; Transforming Growth Factor beta / analysis
Abstract
Hertwig's epithelial root sheath (HERS) plays an important role in tooth root formation. In this study, we examined root formation of the first molar in mice, focusing on cell proliferation, cell death, cell migration, and the expression patterns of the signaling molecules, including glycoproteins and proteoglycans between PN8 and PN26. The number of HERS cells decreased during root formation, although HERS retained total length until PN15. The migration of HERS cells did not occur during root formation. Moreover, the immunopositive reaction of laminin beta-3 and syndecan-1 in HERS indicates that both cell adhesion and cell proliferation are essential for HERS development. Bmp-2, Bmp-4, and Msx-2 were expressed in HERS cells during root formation. We also developed an in vitro culture system for investigating the periodontium and suggest that this system provides an excellent vehicle for full exploration, and hence improved understanding, of the development and regeneration of the periodontium. Together, our results provide a comprehensive model describing the morphogenesis of early root development in vertebrates.
Full Text
https://journals.sagepub.com/doi/10.1177/154405910408300906
DOI
10.1177/154405910408300906
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178797
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