Cited 17 times in
Nephroblastoma overexpressed gene (NOV) expression in rat hepatic stellate cells
DC Field | Value | Language |
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dc.contributor.author | 박영년 | - |
dc.date.accessioned | 2020-09-04T02:04:47Z | - |
dc.date.available | 2020-09-04T02:04:47Z | - |
dc.date.issued | 2004-10 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/178787 | - |
dc.description.abstract | Using the expression-profiling method, we identified nephroblastoma overexpressed gene (NOV) mRNA as one member of the mRNA population that was upregulated in cultured activated hepatic stellate cell (HSC). Northern analysis showed that NOV mRNA was increasingly expressed during progressive activation of cultured rat HSCs, and a significant increase was observed in both the carbon tetrachloride-induced and bile duct ligation/scission rat models of liver fibrosis. RT-PCR showed human NOV mRNA was increased in most fibrotic livers compared with normal livers. The expression of NOV protein in fibrotic rat and human livers was predominantly located in areas of ductular proliferation and HSC of the fibrous septa. HSCs stimulated with transforming growth factor beta1 showed increased expression of NOV protein without changing its mRNA levels. Dexamethasone stimulated the expression of NOV mRNA and protein. Furthermore, we demonstrated that bile acids have a modulating effect on the induction of NOV mRNA expression. In conclusion, this study suggests that NOV is expressed during liver fibrogenesis and HSCs may be an important source of hepatic NOV. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | BIOCHEMICAL PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bile Acids and Salts / pharmacology | - |
dc.subject.MESH | Connective Tissue Growth Factor | - |
dc.subject.MESH | Dexamethasone / pharmacology | - |
dc.subject.MESH | Gene Expression* / drug effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immediate-Early Proteins / metabolism* | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Intercellular Signaling Peptides and Proteins / metabolism* | - |
dc.subject.MESH | Liver / metabolism | - |
dc.subject.MESH | Liver Cirrhosis / metabolism | - |
dc.subject.MESH | Nephroblastoma Overexpressed Protein | - |
dc.subject.MESH | RNA, Messenger / drug effects | - |
dc.subject.MESH | RNA, Messenger / metabolism | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Stellate Ganglion / cytology* | - |
dc.subject.MESH | Stellate Ganglion / metabolism | - |
dc.subject.MESH | Transforming Growth Factor beta / pharmacology | - |
dc.subject.MESH | Transforming Growth Factor beta1 | - |
dc.title | Nephroblastoma overexpressed gene (NOV) expression in rat hepatic stellate cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Sung Hee Lee | - |
dc.contributor.googleauthor | Geom Seog Seo | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.contributor.googleauthor | Dong Hwan Sohn | - |
dc.identifier.doi | 10.1016/j.bcp.2004.06.009 | - |
dc.contributor.localId | A01563 | - |
dc.relation.journalcode | J00283 | - |
dc.identifier.eissn | 1873-2968 | - |
dc.identifier.pmid | 15345329 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S000629520400423X | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | 박영년 | - |
dc.citation.volume | 68 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1391 | - |
dc.citation.endPage | 1400 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL PHARMACOLOGY, Vol.68(7) : 1391-1400, 2004-10 | - |
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