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신경병증성 통증 모델에서 capsaicin 약침의 통증 억제 효과

Other Titles
 Analgesic Effect of Capsaicin Acupuncture on Neuropathic Pain in Rats 
Authors
 신다은  ;  차명훈  ;  배선준  ;  사영희  ;  이배환 
Citation
 Journal of Applied Micromagnetic Energy (응용미약에너지학회지), Vol.9(1) : 10-15, 2011-06 
Journal Title
Journal of Applied Micromagnetic Energy(응용미약에너지학회지)
ISSN
 1738-4427 
Issue Date
2011-06
Keywords
Capsaicin ; pharmaceutical acupuncture ; neupathic pain ; c-Fos immunohistochemistry
Abstract
Acupuncture combined with pharmaceutical agents has been used to treat diseases in humans and
animals. Capsaicin can relieve pain by desensitization. The present study was conducted to determine whether capsaicin
acupuncture as one of pharmaceutical acupunctures can relieve neuropathic pain effectively. 14 days after neuropathic
injury, capsaicin was injected at Zusanli acupoint (ST36) and behavioral test was conducted using von Frey filament.
After behavioral test, animals were perfused by 4% paraformaldehyde solution. The lumbar spinal cord was then
removed and immunohistochemistry was performed to observe c-Fos expression. Capsaicin injected at ST36 acupoint
inhibited neuropathic pain behaviors. c-Fos expression level in the lumbar spinal cord had a tendency to decrease in rats
treated with capsaicin acupuncture. These results suggest that capsaicin acupuncture as one of pharmaceutical
acupunctures may be effective in relieving neuropathic pain.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Bai, Sun Joon(배선준) ORCID logo https://orcid.org/0000-0001-5027-3232
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
Cha, Myeoung Hoon(차명훈) ORCID logo https://orcid.org/0000-0002-7993-672X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178663
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