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Alterations in lipid profile of autistic boys: a case control study
DC Field | Value | Language |
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dc.contributor.author | 신증수 | - |
dc.date.accessioned | 2020-08-14T03:15:24Z | - |
dc.date.available | 2020-08-14T03:15:24Z | - |
dc.date.issued | 2010-04 | - |
dc.identifier.issn | 0271-5317 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/178651 | - |
dc.description.abstract | We hypothesize that autism is associated with alterations in the plasma lipid profile and that some lipid fractions in autistic boys may be significantly different than those of healthy boys. A matched case control study was conducted with 29 autistic boys (mean age, 10.1 +/- 1.3 years) recruited from a school for disabled children and 29 comparable healthy boys from a neighboring elementary school in South Korea. Fasting plasma total cholesterol (T-Chol), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), the LDL/HDL ratio, and 1-day food intakes were measured. Multiple regression analyses were performed to assess the association between autism and various lipid fractions. The mean TG level (102.4 +/- 52.4 vs 70.6 +/- 36.3; P = .01) was significantly higher, whereas the mean HDL-C level (48.8 +/- 11.9 vs 60.5 +/- 10.9 mg/dL; P = .003) was significantly lower in cases as compared to controls. There was no significant difference in T-Chol and LDL-C levels between cases and controls. The LDL/HDL ratio was significantly higher in cases as compared to controls. Multiple regression analyses indicated that autism was significantly associated with plasma TG (beta = 31.7 +/- 11.9; P = .01), HDL (beta = -11.6 +/- 2.1; P = .0003), and the LDL/HDL ratio (beta = 0.40 +/- 0.18; P = .04). There was a significant interaction between autism and TG level in relation to plasma HDL level (P = .02). Fifty-three percent of variation in the plasma HDL was explained by autism, plasma TG, LDL/HDL ratio, and the interaction between autism and plasma TG level. These results indicate the presence of dyslipidemia in boys with autism and suggest a possibility that dyslipidemia might be a marker of association between lipid metabolism and autism. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | NUTRITION RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Autistic Disorder / blood* | - |
dc.subject.MESH | Autistic Disorder / complications | - |
dc.subject.MESH | Biomarkers / blood | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Cholesterol, HDL / blood | - |
dc.subject.MESH | Cholesterol, LDL / blood | - |
dc.subject.MESH | Dyslipidemias / complications* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lipids / blood* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Regression Analysis | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Triglycerides / blood | - |
dc.title | Alterations in lipid profile of autistic boys: a case control study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Eun-Kyung Kim | - |
dc.contributor.googleauthor | Yasmin H Neggers | - |
dc.contributor.googleauthor | Cheung-Soo Shin | - |
dc.contributor.googleauthor | Eunkyeong Kim | - |
dc.contributor.googleauthor | Eun Mi Kim | - |
dc.contributor.localId | A02159 | - |
dc.relation.journalcode | J02401 | - |
dc.identifier.eissn | 1879-0739 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0271531710000461 | - |
dc.contributor.alternativeName | Shin, Cheung Soo | - |
dc.contributor.affiliatedAuthor | 신증수 | - |
dc.citation.volume | 30 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 255 | - |
dc.citation.endPage | 260 | - |
dc.identifier.bibliographicCitation | NUTRITION RESEARCH, Vol.30(4) : 255-260, 2010-04 | - |
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