Cited 2 times in
Treatment of lamivudine-resistant chronic hepatitis B infection: a multicenter retrospective study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안상훈 | - |
dc.date.accessioned | 2020-07-27T16:46:19Z | - |
dc.date.available | 2020-07-27T16:46:19Z | - |
dc.date.issued | 2013-02 | - |
dc.identifier.issn | 0036-5521 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/178518 | - |
dc.description.abstract | Objectives: To compare the efficacy of rescue therapies in lamivudine (LAM)-resistant chronic hepatitis B (CHB) infections including: (1) adefovir dipivoxil (ADV) monotherapy, (2) ADV plus LAM combination therapy and (3) entecavir (ETV) 1.0 mg monotherapy. Materials and methods: The authors designed a multicenter-retrospective study. Eight institutions participated in the study from Korea. Results: A total of 343 LAM-resistant CHB patients were enrolled. The proportion of patients with undetectable serum hepatitis B virus (HBV) DNA levels at month 24 after the initiation of rescue therapy was higher in the ADV plus LAM combination therapy group (39/64, 60.9%) than in the ADV monotherapy (50/126, 39.7%) and ETV 1.0 mg monotherapy (19/48, 39.6%) groups (p = 0.014). Mean serum HBV DNA levels at 24 months were 2.07 ± 1.21 log(10) IU/ml in the ADV plus LAM combination therapy group, 2.74 ± 1.74 log(10) IU/ml in the ADV monotherapy group and 3.08 ± 1.97 log(10) IU/ml in the ETV 1.0 mg monotherapy group (p = 0.014). In multivariate analysis, a finding of undetectable serum HBV DNA level at 6 months and ADV plus LAM combination therapy (vs. ADV) was an independent factor for predicting undetectable serum HBV DNA at month 24 (odds ratio, 1.003; 95% confidence interval, 1.000-1.006; p = 0.026). Conclusions: ADV plus LAM combination therapy is more effective in reducing viral load than switching to ADV or ETV 1.0 mg in patients with LAM-resistant CHB. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Informa Healthcare | - |
dc.relation.isPartOf | SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adenine / analogs & derivatives* | - |
dc.subject.MESH | Adenine / therapeutic use | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antiviral Agents / therapeutic use* | - |
dc.subject.MESH | Drug Administration Schedule | - |
dc.subject.MESH | Drug Resistance, Viral* | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Guanine / analogs & derivatives* | - |
dc.subject.MESH | Guanine / therapeutic use | - |
dc.subject.MESH | Hepatitis B, Chronic / drug therapy* | - |
dc.subject.MESH | Hepatitis B, Chronic / virology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Lamivudine / therapeutic use* | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Organophosphonates / therapeutic use* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Viral Load | - |
dc.title | Treatment of lamivudine-resistant chronic hepatitis B infection: a multicenter retrospective study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sun Jae Lee | - |
dc.contributor.googleauthor | Hyung Joon Yim | - |
dc.contributor.googleauthor | Seong Gyu Hwang | - |
dc.contributor.googleauthor | Yeon Seok Seo | - |
dc.contributor.googleauthor | Ji Hoon Kim | - |
dc.contributor.googleauthor | Eileen L Yoon | - |
dc.contributor.googleauthor | Joong Min Lee | - |
dc.contributor.googleauthor | Bo Hyun Kim | - |
dc.contributor.googleauthor | Sang Jong Park | - |
dc.contributor.googleauthor | Young Min Park | - |
dc.contributor.googleauthor | Hong Soo Kim | - |
dc.contributor.googleauthor | Se Hwan Lee | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Jeong Il Lee | - |
dc.contributor.googleauthor | Jin Woo Lee | - |
dc.contributor.googleauthor | In Hee Kim | - |
dc.contributor.googleauthor | Hyung Soo Kim | - |
dc.contributor.googleauthor | Sun Pyo Hong | - |
dc.identifier.doi | 10.3109/00365521.2012.722671 | - |
dc.contributor.localId | A02226 | - |
dc.relation.journalcode | J02632 | - |
dc.identifier.eissn | 1502-7708 | - |
dc.identifier.pmid | 23194375 | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.3109/00365521.2012.722671 | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | 안상훈 | - |
dc.citation.volume | 48 | - |
dc.citation.startPage | 196 | - |
dc.citation.endPage | 204 | - |
dc.identifier.bibliographicCitation | SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, Vol.48 : 196-204, 2013-02 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.