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Evaluation of lymph node metastases: comparison of gadofluorine M-enhanced MRI and diffusion-weighted MRI in a rabbit VX2 rectal cancer model

Authors
 Seung Ho Kim  ;  Jeong Min Lee  ;  Sung Kyoung Moon  ;  Yong Eun Chung  ;  Jin Ho Paik  ;  Seung Hong Choi  ;  Min Uk Kim  ;  Joon Koo Han  ;  Byung Ihn Choi 
Citation
 JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol.35(5) : 1179-1186, 2012-05 
Journal Title
 JOURNAL OF MAGNETIC RESONANCE IMAGING 
ISSN
 1053-1807 
Issue Date
2012-05
MeSH
Animals ; Cell Line, Tumor ; Contrast Media* ; Diffusion Magnetic Resonance Imaging ; Disease Models, Animal ; Image Enhancement / methods* ; Lymphatic Metastasis / diagnosis* ; Magnetic Resonance Imaging / methods* ; Neoplasm Transplantation ; Neoplasms, Experimental ; Organometallic Compounds* ; ROC Curve ; Rabbits ; Rectal Neoplasms / pathology* ; Sensitivity and Specificity
Abstract
Purpose: To compare the diagnostic performance of a diffusion-weighted imaging (DWI) dataset and a gadofluorine M-enhanced imaging dataset for identifying lymph node (LN) metastases in a rabbit rectal cancer model. Materials and methods: VX2 carcinomas were injected into the rectum of 26 rabbits. Four weeks later, T2-weighted imaging (T2WI), pre-T1WI, DWI, and post-T1WI were performed. Two radiologists independently reviewed the DWI set (T2WI, pre-T1WI, DWI) and the gadofluorine M set (T2WI, pre- and post-T1WI) and recorded their confidence scores for LN metastasis on a per-LN basis. Receiver operating characteristic (ROC) analysis was performed to compare the area under the ROC curve (A(z) ) of the two imaging sets. Histopathologic results were used as the reference standard. Results: The A(z) and sensitivity of the gadofluorine M set were comparable to those of the DWI set (A(z) , for reader 1, 0.849, 0.829, P = 0.571; for reader 2, 0.923, 0.876, P = 0.212; sensitivity, for reader 1, 97%, 97%; for reader 2, 97%, 92%, P = 0.304). The specificity of the former was greater than that of the latter (for reader 1, 65%, 53%, P = 0.0003; for reader 2, 81%, 68%, P = 0.01). Conclusion: Gadofluorine M-enhanced images provided greater specificity than DWI for identifying LN metastases, whereas the A(z) and sensitivity of the former were comparable to those of the latter.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/jmri.23513
DOI
10.1002/jmri.23513
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Chung, Yong Eun(정용은) ORCID logo https://orcid.org/0000-0003-0811-9578
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178489
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