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Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2

Authors
 Young-Bock Shim  ;  Hong-Hee Jung  ;  Ju Woong Jang  ;  Hee Seok Yang  ;  Hojae Bae  ;  Jong-Chul Park  ;  Bogyu Choi  ;  Soo-Hong Lee 
Citation
 JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, Vol.37 : 101-106, 2016-05 
Journal Title
 JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY 
ISSN
 1226-086X 
Issue Date
2016-05
Keywords
PLGA ; Hollow porous microspheres ; Sucrose ; Dexamethasone ; BMP2
Abstract
Hollow porous poly(d,l-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using the water-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Col1) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount of Col1. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MS could be fabricated successfully using sucrose and showed great potential as a controlled dual drug delivery system.
Full Text
https://www.sciencedirect.com/science/article/pii/S1226086X1630017X#!
DOI
10.1016/j.jiec.2016.03.014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178488
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