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Toward male individualization with rapidly mutating y-chromosomal short tandem repeats

DC FieldValueLanguage
dc.contributor.author신경진-
dc.date.accessioned2020-07-27T16:42:37Z-
dc.date.available2020-07-27T16:42:37Z-
dc.date.issued2014-08-
dc.identifier.issn1059-7794-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/178473-
dc.description.abstractRelevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father-son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfHUMAN MUTATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAfrica-
dc.subject.MESHAlleles-
dc.subject.MESHAmericas-
dc.subject.MESHAsia-
dc.subject.MESHChromosomes, Human, Y / chemistry*-
dc.subject.MESHDNA Fingerprinting / methods*-
dc.subject.MESHDNA Fingerprinting / statistics & numerical data-
dc.subject.MESHEurope-
dc.subject.MESHGene Frequency-
dc.subject.MESHGenetic Variation-
dc.subject.MESHGenetics, Population*-
dc.subject.MESHHaplotypes*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMicrosatellite Repeats*-
dc.subject.MESHPaternity-
dc.subject.MESHPedigree-
dc.subject.MESHRural Population-
dc.subject.MESHUrban Population-
dc.titleToward male individualization with rapidly mutating y-chromosomal short tandem repeats-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Forensic Medicine (법의학과)-
dc.contributor.googleauthorKaye N Ballantyne-
dc.contributor.googleauthorArwin Ralf-
dc.contributor.googleauthorRachid Aboukhalid-
dc.contributor.googleauthorNiaz M Achakzai-
dc.contributor.googleauthorMaria J Anjos-
dc.contributor.googleauthorQasim Ayub-
dc.contributor.googleauthorJože Balažic-
dc.contributor.googleauthorJack Ballantyne-
dc.contributor.googleauthorDavid J Ballard-
dc.contributor.googleauthorBurkhard Berger-
dc.contributor.googleauthorCecilia Bobillo-
dc.contributor.googleauthorMehdi Bouabdellah-
dc.contributor.googleauthorHelen Burri-
dc.contributor.googleauthorTomas Capal-
dc.contributor.googleauthorStefano Caratti-
dc.contributor.googleauthorJorge Cárdenas-
dc.contributor.googleauthorFrançois Cartault-
dc.contributor.googleauthorElizeu F Carvalho-
dc.contributor.googleauthorMonica Carvalho-
dc.contributor.googleauthorBaowen Cheng-
dc.contributor.googleauthorMichael D Coble-
dc.contributor.googleauthorDavid Comas-
dc.contributor.googleauthorDaniel Corach-
dc.contributor.googleauthorMaria E D'Amato-
dc.contributor.googleauthorSean Davison-
dc.contributor.googleauthorPeter de Knijff-
dc.contributor.googleauthorMaria Corazon A De Ungria-
dc.contributor.googleauthorRonny Decorte-
dc.contributor.googleauthorTadeusz Dobosz-
dc.contributor.googleauthorBerit M Dupuy-
dc.contributor.googleauthorSamir Elmrghni-
dc.contributor.googleauthorMateusz Gliwiński-
dc.contributor.googleauthorSara C Gomes-
dc.contributor.googleauthorLaurens Grol-
dc.contributor.googleauthorCordula Haas-
dc.contributor.googleauthorErin Hanson-
dc.contributor.googleauthorJürgen Henke-
dc.contributor.googleauthorLotte Henke-
dc.contributor.googleauthorFabiola Herrera-Rodríguez-
dc.contributor.googleauthorCarolyn R Hill-
dc.contributor.googleauthorGunilla Holmlund-
dc.contributor.googleauthorKatsuya Honda-
dc.contributor.googleauthorUta-Dorothee Immel-
dc.contributor.googleauthorShota Inokuchi-
dc.contributor.googleauthorMark A Jobling-
dc.contributor.googleauthorMahmoud Kaddura-
dc.contributor.googleauthorJong S Kim-
dc.contributor.googleauthorSoon H Kim-
dc.contributor.googleauthorWook Kim-
dc.contributor.googleauthorTuri E King-
dc.contributor.googleauthorEva Klausriegler-
dc.contributor.googleauthorDaniel Kling-
dc.contributor.googleauthorLejla Kovačević-
dc.contributor.googleauthorLeda Kovatsi-
dc.contributor.googleauthorPaweł Krajewski-
dc.contributor.googleauthorSergey Kravchenko-
dc.contributor.googleauthorMaarten H D Larmuseau-
dc.contributor.googleauthorEun Young Lee-
dc.contributor.googleauthorRuediger Lessig-
dc.contributor.googleauthorLudmila A Livshits-
dc.contributor.googleauthorDamir Marjanović-
dc.contributor.googleauthorMarek Minarik-
dc.contributor.googleauthorNatsuko Mizuno-
dc.contributor.googleauthorHelena Moreira-
dc.contributor.googleauthorNiels Morling-
dc.contributor.googleauthorMeeta Mukherjee-
dc.contributor.googleauthorPatrick Munier-
dc.contributor.googleauthorJavaregowda Nagaraju-
dc.contributor.googleauthorFranz Neuhuber-
dc.contributor.googleauthorShengjie Nie-
dc.contributor.googleauthorPremlaphat Nilasitsataporn-
dc.contributor.googleauthorTakeki Nishi-
dc.contributor.googleauthorHye H Oh-
dc.contributor.googleauthorJill Olofsson-
dc.contributor.googleauthorValerio Onofri-
dc.contributor.googleauthorJukka U Palo-
dc.contributor.googleauthorHorolma Pamjav-
dc.contributor.googleauthorWalther Parson-
dc.contributor.googleauthorMichal Petlach-
dc.contributor.googleauthorChristopher Phillips-
dc.contributor.googleauthorRafal Ploski-
dc.contributor.googleauthorSamayamantri P R Prasad-
dc.contributor.googleauthorDragan Primorac-
dc.contributor.googleauthorGludhug A Purnomo-
dc.contributor.googleauthorJosephine Purps-
dc.contributor.googleauthorHector Rangel-Villalobos-
dc.contributor.googleauthorKrzysztof Rębała-
dc.contributor.googleauthorBudsaba Rerkamnuaychoke-
dc.contributor.googleauthorDanel Rey Gonzalez-
dc.contributor.googleauthorCarlo Robino-
dc.contributor.googleauthorLutz Roewer-
dc.contributor.googleauthorAlexandra Rosa-
dc.contributor.googleauthorAntti Sajantila-
dc.contributor.googleauthorAndrea Sala-
dc.contributor.googleauthorJazelyn M Salvador-
dc.contributor.googleauthorPaula Sanz-
dc.contributor.googleauthorCornelia Schmitt-
dc.contributor.googleauthorAnil K Sharma-
dc.contributor.googleauthorDayse A Silva-
dc.contributor.googleauthorKyoung-Jin Shin-
dc.contributor.googleauthorTitia Sijen-
dc.contributor.googleauthorMiriam Sirker-
dc.contributor.googleauthorDaniela Siváková-
dc.contributor.googleauthorVedrana Skaro-
dc.contributor.googleauthorCarlos Solano-Matamoros-
dc.contributor.googleauthorLuis Souto-
dc.contributor.googleauthorVlastimil Stenzl-
dc.contributor.googleauthorHerawati Sudoyo-
dc.contributor.googleauthorDenise Syndercombe-Court-
dc.contributor.googleauthorAdriano Tagliabracci-
dc.contributor.googleauthorDuncan Taylor-
dc.contributor.googleauthorAndreas Tillmar-
dc.contributor.googleauthorIosif S Tsybovsky-
dc.contributor.googleauthorChris Tyler-Smith-
dc.contributor.googleauthorKristiaan J van der Gaag-
dc.contributor.googleauthorDaniel Vanek-
dc.contributor.googleauthorAntónia Völgyi-
dc.contributor.googleauthorDenise Ward-
dc.contributor.googleauthorPatricia Willemse-
dc.contributor.googleauthorEric P H Yap-
dc.contributor.googleauthorRita Y Y Yong-
dc.contributor.googleauthorIrena Zupanič Pajnič-
dc.contributor.googleauthorManfred Kayser-
dc.identifier.doi10.1002/humu.22599-
dc.contributor.localIdA02085-
dc.relation.journalcodeJ01010-
dc.identifier.eissn1098-1004-
dc.identifier.pmid24917567-
dc.subject.keywordRM Y-STRs-
dc.subject.keywordY-STRs-
dc.subject.keywordY-chromosome-
dc.subject.keywordforensic-
dc.subject.keywordhaplotypes-
dc.subject.keywordpaternal lineage-
dc.contributor.alternativeNameShin, Kyoung Jin-
dc.contributor.affiliatedAuthor신경진-
dc.citation.volume35-
dc.citation.number8-
dc.citation.startPage1021-
dc.citation.endPage1032-
dc.identifier.bibliographicCitationHUMAN MUTATION, Vol.35(8) : 1021-1032, 2014-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Forensic Medicine (법의학과) > 1. Journal Papers

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