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Elevated Metabolites of Steroidogenesis and Amino Acid Metabolism in Preadolescent Female Children With High Urinary Bisphenol A Levels: A High-Resolution Metabolomics Study

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dc.contributor.author지선하-
dc.date.accessioned2020-07-16T16:53:05Z-
dc.date.available2020-07-16T16:53:05Z-
dc.date.issued2017-12-
dc.identifier.issn1096-6080-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/178368-
dc.description.abstractHealth risks associated with bisphenol A (BPA) exposure are controversially highlighted by numerous studies. High-resolution metabolomics (HRM) can confirm these proposed associations and may provide a mechanistic insight into the connections between BPA exposure and metabolic perturbations. This study was aimed to identify the changes in metabolomics profile due to BPA exposure in urine and serum samples collected from female and male children (n = 18) aged 7-9. Urine was measured for BPA concentration, and the children were subsequently classified into high and low BPA groups. HRM, coupled with Liquid chromatography-mass spectrometry/MS, followed by multivariate statistical analysis using MetaboAnalyst 3.0, were performed on urine to discriminate metabolic profiles between high and low BPA children as well as males and females, followed by further validation of our findings in serum samples obtained from same population. Metabolic pathway analysis showed that biosynthesis of steroid hormones and 7 other pathways-amino acid and nucleotide biosynthesis, phenylalanine metabolism, tryptophan metabolism, tyrosine metabolism, lysine degradation, pyruvate metabolism, and arginine biosynthesis-were affected in high BPA children. Elevated levels of metabolites associated with these pathways in urine and serum were mainly observed in female children, while these changes were negligible in male children. Our results suggest that the steroidogenesis pathway and amino acid metabolism are the main targets of perturbation by BPA in preadolescent girls.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherOxford University Press-
dc.relation.isPartOfTOXICOLOGICAL SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAge Factors-
dc.subject.MESHAmino Acids / blood*-
dc.subject.MESHAmino Acids / urine*-
dc.subject.MESHBenzhydryl Compounds / toxicity-
dc.subject.MESHBenzhydryl Compounds / urine*-
dc.subject.MESHBiomarkers / blood-
dc.subject.MESHBiomarkers / urine-
dc.subject.MESHChild-
dc.subject.MESHChromatography, High Pressure Liquid*-
dc.subject.MESHEndocrine Disruptors / toxicity-
dc.subject.MESHEndocrine Disruptors / urine*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMetabolomics / methods*-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHPhenols / toxicity-
dc.subject.MESHPhenols / urine*-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHRisk Assessment-
dc.subject.MESHSex Factors-
dc.subject.MESHSpectrometry, Mass, Electrospray Ionization*-
dc.subject.MESHSteroids / biosynthesis-
dc.subject.MESHSteroids / blood*-
dc.subject.MESHSteroids / urine*-
dc.subject.MESHUp-Regulation-
dc.subject.MESHUrinalysis-
dc.titleElevated Metabolites of Steroidogenesis and Amino Acid Metabolism in Preadolescent Female Children With High Urinary Bisphenol A Levels: A High-Resolution Metabolomics Study-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorAdnan Khan-
dc.contributor.googleauthorHyesook Park-
dc.contributor.googleauthorHye Ah Lee-
dc.contributor.googleauthorBohyun Park-
dc.contributor.googleauthorHye Sun Gwak-
dc.contributor.googleauthorHye-Ra Lee-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorYoungja H Park-
dc.identifier.doi10.1093/toxsci/kfx189-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ02740-
dc.identifier.eissn1096-0929-
dc.identifier.pmid28973422-
dc.identifier.urlhttps://academic.oup.com/toxsci/article/160/2/371/4110197-
dc.subject.keywordendocrine disruptors-
dc.subject.keywordpreadolescent toxicity-
dc.subject.keywordsex effects-
dc.subject.keywordsteroidogenesis pathway-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthor지선하-
dc.citation.volume160-
dc.citation.number2-
dc.citation.startPage371-
dc.citation.endPage385-
dc.identifier.bibliographicCitationTOXICOLOGICAL SCIENCES, Vol.160(2) : 371-385, 2017-12-
dc.identifier.rimsid64788-
dc.type.rimsART-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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