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국내 개발된 Modified Bovine Lung Surfactant의 물리학적 및 생물학적 활성도

DC FieldValueLanguage
dc.contributor.author남궁란-
dc.contributor.author박국인-
dc.contributor.author박민수-
dc.contributor.author이철-
dc.contributor.author박국인-
dc.contributor.author박민수-
dc.contributor.author이철-
dc.date.accessioned2020-07-03T18:01:57Z-
dc.date.available2020-07-03T18:01:57Z-
dc.date.issued1997-
dc.identifier.issn0560-3560-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/177970-
dc.description.abstractPurpose : Neonatal respiratory distress syndrome is caused by the deficiency of lung surfactant in premature babies. For the treatment of RDS at present surfactants such as Surfacten․ (Tokyo-Tanabe Co., Japan) and Exosurf․ (Wellcome Co., USA) are used. As awarded the grant from the Ministry of Science and Technology for a model research project of Medium-Technology program, we have modified (supplemented) the bovine lung extracts to get YY-38, for which we have performed physical and biological activities. Methods : For physical properties, we performed stable microbubble test (SMR) and measured surface tension lowering activity using a pulsating bubble surfactometer. Minimum and maximum surface tensions measured at 1 and 5 minutes gave surface tension-surface area diagrams, from which compressibility at surface tension 10mN/m was also calculated. As to the biological activity, we used premature rabbit fetuses as a model for the study of pressure-lung volume relationship. The lung pathology was examined on the lung tissues subsequently obtained, and aerated area ratios were calculated based on the area measured by an image analyzer. Results : The minimum surface tensions of YY-38 at 1 and 5 minutes for all different concentrations were low at 10mN/m, while the maximum surface tensions ranged from 33.01mN/m to 41.07mN/m. The surface tension-surface area curve showed a definite hysteresis at 1 and 5 minutes for all concentrations, and the surface tension fell below 10mN/m with 20% surface area compression. The compressibilities at surface tension 10mN/m at 5minutes for all concentrations were all below 0.02. In animal experiments, the mean lung volume of premature rabbit fetuses was inflated to 80.9ml/kg at maximum 30cmH2O, while the lung volume was maintained at 38.3mg/kg when the lung was deflated to 5cmH2O. The overall aerated area ratio was 45.4%. Conclusion : YY-38 formed sufficient amount of stable microbubbles and had a surface tension low enough to maintain alveolar stability and to exhibit a good hysteresis curve. In animal experiments it helped the expansion of premature lungs during inspiratory phase and was effective in the prevention of collapse during expiratory phase.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한소아과학회-
dc.relation.isPartOfJournal of the Korean Pediatric Association (소아과)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title국내 개발된 Modified Bovine Lung Surfactant의 물리학적 및 생물학적 활성도-
dc.title.alternativePhysical and Biological Activity of Domestic Product of Modified Bovine Lung Surfactant-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.googleauthor이철-
dc.contributor.googleauthor박민수-
dc.contributor.googleauthor박문성-
dc.contributor.googleauthor김정년-
dc.contributor.googleauthor이종욱-
dc.contributor.googleauthor유광현-
dc.contributor.googleauthor곽원재-
dc.contributor.googleauthor박국인-
dc.contributor.googleauthor남궁란-
dc.contributor.googleauthor한동관-
dc.contributor.localIdA01241-
dc.contributor.localIdA01438-
dc.contributor.localIdA01438-
dc.contributor.localIdA01468-
dc.contributor.localIdA01468-
dc.contributor.localIdA03253-
dc.contributor.localIdA03253-
dc.contributor.localIdA01438-
dc.contributor.localIdA01438-
dc.contributor.localIdA01468-
dc.contributor.localIdA01468-
dc.contributor.localIdA03253-
dc.contributor.localIdA03253-
dc.relation.journalcodeJ01842-
dc.contributor.alternativeNameNamgung, Ran-
dc.contributor.affiliatedAuthor남궁란-
dc.contributor.affiliatedAuthor박국인-
dc.contributor.affiliatedAuthor박국인-
dc.contributor.affiliatedAuthor박민수-
dc.contributor.affiliatedAuthor박민수-
dc.contributor.affiliatedAuthor이철-
dc.contributor.affiliatedAuthor이철-
dc.contributor.affiliatedAuthor박국인-
dc.contributor.affiliatedAuthor박국인-
dc.contributor.affiliatedAuthor박민수-
dc.contributor.affiliatedAuthor박민수-
dc.contributor.affiliatedAuthor이철-
dc.contributor.affiliatedAuthor이철-
dc.citation.volume40-
dc.citation.number6-
dc.citation.startPage771-
dc.citation.endPage785-
dc.identifier.bibliographicCitationJournal of the Korean Pediatric Association (소아과), Vol.40(6) : 771-785, 1997-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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