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국내 개발된 Modified Bovine Lung Surfactant의 물리학적 및 생물학적 활성도
DC Field | Value | Language |
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dc.contributor.author | 남궁란 | - |
dc.contributor.author | 박국인 | - |
dc.contributor.author | 박민수 | - |
dc.contributor.author | 이철 | - |
dc.date.accessioned | 2020-07-03T18:01:57Z | - |
dc.date.available | 2020-07-03T18:01:57Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0560-3560 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177970 | - |
dc.description.abstract | Purpose : Neonatal respiratory distress syndrome is caused by the deficiency of lung surfactant in premature babies. For the treatment of RDS at present surfactants such as Surfacten․ (Tokyo-Tanabe Co., Japan) and Exosurf․ (Wellcome Co., USA) are used. As awarded the grant from the Ministry of Science and Technology for a model research project of Medium-Technology program, we have modified (supplemented) the bovine lung extracts to get YY-38, for which we have performed physical and biological activities. Methods : For physical properties, we performed stable microbubble test (SMR) and measured surface tension lowering activity using a pulsating bubble surfactometer. Minimum and maximum surface tensions measured at 1 and 5 minutes gave surface tension-surface area diagrams, from which compressibility at surface tension 10mN/m was also calculated. As to the biological activity, we used premature rabbit fetuses as a model for the study of pressure-lung volume relationship. The lung pathology was examined on the lung tissues subsequently obtained, and aerated area ratios were calculated based on the area measured by an image analyzer. Results : The minimum surface tensions of YY-38 at 1 and 5 minutes for all different concentrations were low at 10mN/m, while the maximum surface tensions ranged from 33.01mN/m to 41.07mN/m. The surface tension-surface area curve showed a definite hysteresis at 1 and 5 minutes for all concentrations, and the surface tension fell below 10mN/m with 20% surface area compression. The compressibilities at surface tension 10mN/m at 5minutes for all concentrations were all below 0.02. In animal experiments, the mean lung volume of premature rabbit fetuses was inflated to 80.9ml/kg at maximum 30cmH2O, while the lung volume was maintained at 38.3mg/kg when the lung was deflated to 5cmH2O. The overall aerated area ratio was 45.4%. Conclusion : YY-38 formed sufficient amount of stable microbubbles and had a surface tension low enough to maintain alveolar stability and to exhibit a good hysteresis curve. In animal experiments it helped the expansion of premature lungs during inspiratory phase and was effective in the prevention of collapse during expiratory phase. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한소아과학회 | - |
dc.relation.isPartOf | Journal of the Korean Pediatric Association (소아과) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 국내 개발된 Modified Bovine Lung Surfactant의 물리학적 및 생물학적 활성도 | - |
dc.title.alternative | Physical and Biological Activity of Domestic Product of Modified Bovine Lung Surfactant | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.googleauthor | 이철 | - |
dc.contributor.googleauthor | 박민수 | - |
dc.contributor.googleauthor | 박문성 | - |
dc.contributor.googleauthor | 김정년 | - |
dc.contributor.googleauthor | 이종욱 | - |
dc.contributor.googleauthor | 유광현 | - |
dc.contributor.googleauthor | 곽원재 | - |
dc.contributor.googleauthor | 박국인 | - |
dc.contributor.googleauthor | 남궁란 | - |
dc.contributor.googleauthor | 한동관 | - |
dc.contributor.localId | A01241 | - |
dc.contributor.localId | A01438 | - |
dc.contributor.localId | A01468 | - |
dc.contributor.localId | A03253 | - |
dc.relation.journalcode | J01842 | - |
dc.contributor.alternativeName | Namgung, Ran | - |
dc.contributor.affiliatedAuthor | 남궁란 | - |
dc.contributor.affiliatedAuthor | 박국인 | - |
dc.contributor.affiliatedAuthor | 박민수 | - |
dc.contributor.affiliatedAuthor | 이철 | - |
dc.citation.volume | 40 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 771 | - |
dc.citation.endPage | 785 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Pediatric Association (소아과), Vol.40(6) : 771-785, 1997 | - |
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