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유방암에서 Bcl-2 및 p53에 대한 면역화확염색의 임상적 연관성
DC Field | Value | Language |
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dc.contributor.author | 정우희 | - |
dc.date.accessioned | 2020-07-03T17:43:47Z | - |
dc.date.available | 2020-07-03T17:43:47Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0496-6872 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177779 | - |
dc.description.abstract | PURPOSE: Bcl-2 and p53 are known to act as a regulator of apoptosis in breast cancer and we evaluated the significance of these gene expressions and correlation with prognostic factors in breast cancer. MATERIALS AND METHODS: In order to investigate the expression of Bcl-2 and p53, we analyzed immunochemistry staining from paraffin blocks in a series of 80 women with breast cancer. Expression was then compared with the established indicators of prognosis. RESULTS: Bcl-2 positivity was 45% and p53 was 32.2%. No relationships could be observed between bcl-2 and node status,tumor size and also between p53 and node status, differentiation,tumor size. Strong positive relationships were seen between bcl-2 and estrogen receptor (ER) (p<0.0001), progesterone receptor (PR) (p<0.001). p53 also showed relationships with ER and PR (p<0.05) Histologic (p<0.05) and nuclear grade (p<0.05) showed relationships with bcl-2 but not with p53. Inverse relationship was noted between p53 and ER, PR (p<0.05). Inverse relationship was also found between bcl-2 and p53 expression (p<0.001). CONCLUSION: This study suggest that there may be a possibility that bcl-2 and p53 expressions can affect tumor growth and prognosis in breast cancer patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한암학회 | - |
dc.relation.isPartOf | Journal of the Korean Cancer Association (대한암학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 유방암에서 Bcl-2 및 p53에 대한 면역화확염색의 임상적 연관성 | - |
dc.title.alternative | Clinicopathological Correlation of Bcl-2 and p53 Immunohistochemistry in Breast Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | 구자윤 | - |
dc.contributor.googleauthor | 이희대 | - |
dc.contributor.googleauthor | 정우희 | - |
dc.contributor.localId | A03671 | - |
dc.relation.journalcode | J01813 | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | Bcl-2 | - |
dc.subject.keyword | p53 | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | 정우희 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 404 | - |
dc.citation.endPage | 411 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Cancer Association (대한암학회지), Vol.29(3) : 404-411, 1997 | - |
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