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유방암에서 Bcl-2 및 p53에 대한 면역화확염색의 임상적 연관성

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dc.contributor.author정우희-
dc.date.accessioned2020-07-03T17:43:47Z-
dc.date.available2020-07-03T17:43:47Z-
dc.date.issued1997-
dc.identifier.issn0496-6872-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/177779-
dc.description.abstractPURPOSE: Bcl-2 and p53 are known to act as a regulator of apoptosis in breast cancer and we evaluated the significance of these gene expressions and correlation with prognostic factors in breast cancer. MATERIALS AND METHODS: In order to investigate the expression of Bcl-2 and p53, we analyzed immunochemistry staining from paraffin blocks in a series of 80 women with breast cancer. Expression was then compared with the established indicators of prognosis. RESULTS: Bcl-2 positivity was 45% and p53 was 32.2%. No relationships could be observed between bcl-2 and node status,tumor size and also between p53 and node status, differentiation,tumor size. Strong positive relationships were seen between bcl-2 and estrogen receptor (ER) (p<0.0001), progesterone receptor (PR) (p<0.001). p53 also showed relationships with ER and PR (p<0.05) Histologic (p<0.05) and nuclear grade (p<0.05) showed relationships with bcl-2 but not with p53. Inverse relationship was noted between p53 and ER, PR (p<0.05). Inverse relationship was also found between bcl-2 and p53 expression (p<0.001). CONCLUSION: This study suggest that there may be a possibility that bcl-2 and p53 expressions can affect tumor growth and prognosis in breast cancer patients.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한암학회-
dc.relation.isPartOfJournal of the Korean Cancer Association (대한암학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title유방암에서 Bcl-2 및 p53에 대한 면역화확염색의 임상적 연관성-
dc.title.alternativeClinicopathological Correlation of Bcl-2 and p53 Immunohistochemistry in Breast Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthor구자윤-
dc.contributor.googleauthor이희대-
dc.contributor.googleauthor정우희-
dc.contributor.localIdA03671-
dc.relation.journalcodeJ01813-
dc.subject.keywordBreast cancer-
dc.subject.keywordBcl-2-
dc.subject.keywordp53-
dc.contributor.alternativeNameJung, Woo Hee-
dc.contributor.affiliatedAuthor정우희-
dc.citation.volume29-
dc.citation.number3-
dc.citation.startPage404-
dc.citation.endPage411-
dc.identifier.bibliographicCitationJournal of the Korean Cancer Association (대한암학회지), Vol.29(3) : 404-411, 1997-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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