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유방암에서 유세포분석의 의의
DC Field | Value | Language |
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dc.contributor.author | 정우희 | - |
dc.date.accessioned | 2020-07-03T17:43:40Z | - |
dc.date.available | 2020-07-03T17:43:40Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0496-6872 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177777 | - |
dc.description.abstract | PURPOSE: To evaluate the relationship between nuclear DNA contents and prognostic factors and survival in breast cancer patients. MATERIALS AND METHODS: We determined nuclear DNA content from 91 paraffin-embedded malignant breast tumors and evaluated relationship between DNA nuclear content and well-known prognostic indicators of breast cancer and the survival of the patients by statistical analyses. RESULTS: Twenty nine (34.5%) of the 91 tumors examined were diploid, and the remainder (65.5%) contained one or more aneuploid clones. S-phase fraction (SPF) ranged from 1.4 to 68.3% (median 11.2%) and it was higher in aneuploidy tumors than in diploid tumors (p<0.05). Positive axillary lymph nodes were found in 72.7% of the patients who had a tumor with a high SPF (above the median 11.2%) and in 27.3% of those with tumor with low SPF (below median) (p<0.05). The overall survival rate was 96.1% in DNA diploid and 87.6% in DNA aneuploid tumors, showing that DNA ploidy had no prognostic significance in breast cancers. The actuarial survival rates were 96.4% and 86.3% for low and high SPF, respectively (p=0.28). The patients with high SPF showed high disease free survival rate compared to the patients with low SPF but the difference had no statistical significance. CONCLUSION: Our results indicate DNA aneuploid tumors were more prevalent in breast cancer patients with high SPF or lymph node metastasis and larger patient accumulation with longer follow-up period will be helpful to identifiy the relationship between flow- cytometrical analysis and prognosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한암학회 | - |
dc.relation.isPartOf | Journal of the Korean Cancer Association (대한암학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 유방암에서 유세포분석의 의의 | - |
dc.title.alternative | The Significance of DNA Flow-cytometry in Breast Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | 구자윤 | - |
dc.contributor.googleauthor | 이희대 | - |
dc.contributor.googleauthor | 정우희 | - |
dc.contributor.localId | A03671 | - |
dc.relation.journalcode | J01813 | - |
dc.subject.keyword | DNA flow-cytometry | - |
dc.subject.keyword | S-phase fraction | - |
dc.subject.keyword | DNA index | - |
dc.subject.keyword | Breast cancer | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | 정우희 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 738 | - |
dc.citation.endPage | 747 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Cancer Association (대한암학회지), Vol.29(5) : 738-747, 1997 | - |
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