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위암 환자의 혈액 및 조직에서 Urokinase-type Plasminogen Activator 발현의 임상적 의의
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김주항 | - |
dc.contributor.author | 노성훈 | - |
dc.contributor.author | 노재경 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 유내춘 | - |
dc.contributor.author | 정현철 | - |
dc.date.accessioned | 2020-07-03T17:41:50Z | - |
dc.date.available | 2020-07-03T17:41:50Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0496-6872 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177765 | - |
dc.description.abstract | PURPOSE: We measured the gastric cancer tissue uPA and plasminogen activator inhibitor-1 (PAI-1) levels and compared them to those of the peripheral and portal blood levels to evaluate the correlation. MATERIALS AND METHODS: Tissue uPA and PAI-1 levels were measured by ELISA assay (Monozyme, Netherland) in paired 85 normal and cancer tissues resected from gastric cancer patients. In 50 patients, blood uPA and PAI-1 levels were measured from pre- operative peripheral and portal blood, post-operative portal blood. RESULTS: Gastric cancer tissue uPA and PAI-1 levels increased from the early stage. The elevated cancer-to-normal ratios of the uPA and PAI-1 were constant from stage I to IV. There were correlations of uPA between normal and cancer tissues (r2=0.38) and between peripheral and pre-resection portal blood level (r2=0.64). There were no correlations between tissue PAI-1 level and blood PAI-1 levels. However, there were correlations in PAI- 1/uPA ratio between cancer tissue and peripheral blood (r2=0.25), peripheral blood and pre- resection portal blood (r2=0.60). CONCLUSION: Even if the cancer tissue levels of uPA and PAI-1 increased from the early stage of gastric cancer, only blood uPA level correlated with tissue uPA level. A modest correlation found in PAI-1/uPA ratio between cancer tissue and blood suggests applicability of blood PAI-1/uPA ratio in predicting tissue uPA, PAI-1 expression. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한암학회 | - |
dc.relation.isPartOf | Journal of the Korean Cancer Association (대한암학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 위암 환자의 혈액 및 조직에서 Urokinase-type Plasminogen Activator 발현의 임상적 의의 | - |
dc.title.alternative | Clinical Significance of Urokinase-type Plasminogen Activator (uPA) Expression from Serum and Tissue of Gastric Cancer Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 정현철 | - |
dc.contributor.googleauthor | 박준오 | - |
dc.contributor.googleauthor | 권현자 | - |
dc.contributor.googleauthor | 김태수 | - |
dc.contributor.googleauthor | 정희철 | - |
dc.contributor.googleauthor | 공수정 | - |
dc.contributor.googleauthor | 이화영 | - |
dc.contributor.googleauthor | 라선영 | - |
dc.contributor.googleauthor | 유내춘 | - |
dc.contributor.googleauthor | 김주황 | - |
dc.contributor.googleauthor | 노재경 | - |
dc.contributor.googleauthor | 노성훈 | - |
dc.contributor.googleauthor | 민진식 | - |
dc.contributor.googleauthor | 김병수 | - |
dc.contributor.localId | A00945 | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A01290 | - |
dc.contributor.localId | A01316 | - |
dc.contributor.localId | A02457 | - |
dc.contributor.localId | A03773 | - |
dc.relation.journalcode | J01813 | - |
dc.contributor.alternativeName | Kim, Joo Hang | - |
dc.contributor.affiliatedAuthor | 김주항 | - |
dc.contributor.affiliatedAuthor | 노성훈 | - |
dc.contributor.affiliatedAuthor | 노재경 | - |
dc.contributor.affiliatedAuthor | 라선영 | - |
dc.contributor.affiliatedAuthor | 유내춘 | - |
dc.contributor.affiliatedAuthor | 정현철 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 765 | - |
dc.citation.endPage | 773 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Cancer Association (대한암학회지), Vol.29(5) : 765-773, 1997 | - |
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