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생물학적 치료 목표로서 위암에서 Midkine 발현의 탐색

DC FieldValueLanguage
dc.contributor.author김주항-
dc.contributor.author노성훈-
dc.contributor.author노재경-
dc.contributor.author라선영-
dc.contributor.author정현철-
dc.contributor.author정희철-
dc.contributor.author조재용-
dc.contributor.author노성훈-
dc.contributor.author노재경-
dc.contributor.author라선영-
dc.contributor.author정현철-
dc.contributor.author정희철-
dc.contributor.author조재용-
dc.date.accessioned2020-07-03T17:41:37Z-
dc.date.available2020-07-03T17:41:37Z-
dc.date.issued1997-
dc.identifier.issn0496-6872-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/177761-
dc.description.abstractPURPOSE: We studied biological phenotypes of gastric cancer cell lines based on a novel heparin-binding growth/differentiation factor, midkine (MK) expression. MATERIALS AND METHODS: Nine gastric cancer cell lines and 25 gastric cancer tissues were tested for MK expression by Northern blot analysis. Soft agar assay for in vitro tumorigenesis, cross- feeding assay for paracrine angiogenic activity, ELISA for uPA and PAI-1 measurement were performed. RESULTS: MK expression was found in 67% (6/9) of the gastric cancer cell lines, and 56% (14/25) of the primary gastric cancer tissues. Gastric cancer cell lines with MK expression were more tumorigenic in soft agar assay and endothelial cell growth stimulatory in cross-feeding assay than cells which did not express MK. However, urokinase-type plasminogen activator (uPA) expression did not correlate with MK expression. Growth of MK expressing cells was inhibited by a heparin-binding blocking agent, pentosan polysulfate (PPS). In cancer tissues, MK expression correlated with tumor size, suggesting in vivo autocrine and paracrine activity. CONCLUSION: Gastric cancer cells with increased MK gene expression showed increased tumorigenic and angiogenic activity. Therefore, this proliferation promoting activity of MK can be targeted by an anti-heparin binding agent as a biotherapy model in gastric cancer treatment.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한암학회-
dc.relation.isPartOfJournal of the Korean Cancer Association (대한암학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title생물학적 치료 목표로서 위암에서 Midkine 발현의 탐색-
dc.title.alternativeEvaluation of Biologic Phenotype by Midkine Gene Expression in Gastric Cancer as a Target for Biotherapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthor정현철-
dc.contributor.googleauthor라선영-
dc.contributor.googleauthor정희철-
dc.contributor.googleauthor곽현주-
dc.contributor.googleauthor조재용-
dc.contributor.googleauthor공수정-
dc.contributor.googleauthor노성훈-
dc.contributor.googleauthor김주항-
dc.contributor.googleauthor노재경-
dc.contributor.googleauthor민진식-
dc.contributor.googleauthor김병수-
dc.contributor.localIdA00945-
dc.contributor.localIdA01281-
dc.contributor.localIdA01281-
dc.contributor.localIdA01290-
dc.contributor.localIdA01290-
dc.contributor.localIdA01316-
dc.contributor.localIdA01316-
dc.contributor.localIdA03773-
dc.contributor.localIdA03773-
dc.contributor.localIdA03794-
dc.contributor.localIdA03794-
dc.contributor.localIdA03899-
dc.contributor.localIdA03899-
dc.contributor.localIdA01281-
dc.contributor.localIdA01281-
dc.contributor.localIdA01290-
dc.contributor.localIdA01290-
dc.contributor.localIdA01316-
dc.contributor.localIdA01316-
dc.contributor.localIdA03773-
dc.contributor.localIdA03773-
dc.contributor.localIdA03794-
dc.contributor.localIdA03794-
dc.contributor.localIdA03899-
dc.contributor.localIdA03899-
dc.relation.journalcodeJ01813-
dc.subject.keywordGastric cancer-
dc.subject.keywordMidkine-
dc.subject.keywordPentosan polysulfate-
dc.subject.keywordBiotherapy-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.affiliatedAuthor김주항-
dc.contributor.affiliatedAuthor노성훈-
dc.contributor.affiliatedAuthor노성훈-
dc.contributor.affiliatedAuthor노재경-
dc.contributor.affiliatedAuthor노재경-
dc.contributor.affiliatedAuthor라선영-
dc.contributor.affiliatedAuthor라선영-
dc.contributor.affiliatedAuthor정현철-
dc.contributor.affiliatedAuthor정현철-
dc.contributor.affiliatedAuthor정희철-
dc.contributor.affiliatedAuthor정희철-
dc.contributor.affiliatedAuthor조재용-
dc.contributor.affiliatedAuthor조재용-
dc.contributor.affiliatedAuthor노성훈-
dc.contributor.affiliatedAuthor노성훈-
dc.contributor.affiliatedAuthor노재경-
dc.contributor.affiliatedAuthor노재경-
dc.contributor.affiliatedAuthor라선영-
dc.contributor.affiliatedAuthor라선영-
dc.contributor.affiliatedAuthor정현철-
dc.contributor.affiliatedAuthor정현철-
dc.contributor.affiliatedAuthor정희철-
dc.contributor.affiliatedAuthor정희철-
dc.contributor.affiliatedAuthor조재용-
dc.contributor.affiliatedAuthor조재용-
dc.citation.volume29-
dc.citation.number1-
dc.citation.startPage69-
dc.citation.endPage80-
dc.identifier.bibliographicCitationJournal of the Korean Cancer Association (대한암학회지), Vol.29(1) : 69-80, 1997-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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