Mesenchymal chondrosarcoma arising in the central nervous system is extremely rare and most of case described are intracranial. During the last ten years, the authors have encountered three cases of spinal mesenchymal chondrosarcoma; These involved a four-year-old boy, a 29-year-old man, and a 36-year women. Their location was lumbosacral, at the cervicothoracic junction, and in the midcervical area, respectively. The three patients underwent surgery, and microscopic examination revealed mesenchymal chondrosarcoma. The postoperative result was good. The related literature is also reviewed.