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장기간의 추적관찰에 따른 만성 B형 간염의 자연경과
DC Field | Value | Language |
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dc.contributor.author | 김호근 | - |
dc.contributor.author | 박찬일 | - |
dc.date.accessioned | 2020-07-03T17:36:23Z | - |
dc.date.available | 2020-07-03T17:36:23Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 1598-9992 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177691 | - |
dc.description.abstract | Background/Aims: Chronic hepatitis type B is highly-prevalent in Korea. However, few studies about its natural history and prognostic factors have been presented until now. The natural course and long-term prognosis of chronic hepatitis type B varies greatly, and this diversity makes it difficu]t to predict the clinical course of individual patients. The histologic finding is known to be a important prognostic factor. Thus we conducted this study to evaluate the natural history and prognostic factors of chronic hepatitis type B in Korea. Methods: The authors analyzed the clinical courses of 147 patients with clinicopathologically proven chronic hepatitis type B through long-term follow-up from the time of the initial biopsy according to histologic classification. 15 patients had chronic persistent hepatitis(CPH). 61 patients had chronic active hepatitis without bridging necrosis(CAH-BN). 46 patients had chronic hepatitis with bridgung necrosis(CAH+BN). 25 patients had chronic active hepatitis with early cirrhotic change(CAH+LC). They were followed for 24 to 150 months(mean 70.8(+25.8)). Results: The probability of developing cirrhosis in chronic hepatitis type B was 0%, 2%, 10%, 18%, 23%, 28%, 37%, 49%, 54% in 1 year to 9 years, respectively. The 5-year cumulative probability of developing cirrhosis was 9% in CPH, 14% in CAH-BN, 22% in CAH+BN, and 55% in CAH+LC. The significant prognostic factors of developing cirrhosis were age(p<0.01) and histologic classification(p<0.001). The probability of developing decompensated cirrhosis in chronic hepatitis type B was 0%, 0%, 0%, 1%, 5%, 13%, 17%, 28%, and 32% in 1 year to 9 years, respectively. The probability of developing hepatocellular carcinoma(HCC) in chronic hepatitis type B was 0%, 0%, 0%, 1%, 3%, 3%, 6%, 8% and 8% in 1 year to 9 years, respectively. The significant prognostic factor of developing HCC was age. Conclusions: The results of this study explored the natural history and prognostic factors of chronic hepatitis type B. 5-year cumulative probability of developing cirrhosis, decompensated cirrhosis and HCC was 23%, 5% and 3%, respectively. Histologic classification and age were significant prognostic factors for the development of cirrhosis. Age was a significant prognostic factor for the development of HCC. (Korean J Gastroenterol 1997;29:343 - 351) | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean Journal of Gastroenterology | - |
dc.publisher | Korean Journal of Gastroenterology | - |
dc.relation.isPartOf | Korean Journal of Gastroenterology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 장기간의 추적관찰에 따른 만성 B형 간염의 자연경과 | - |
dc.title.alternative | Natural History of Chronic Hepatitis Type B throughout Long-term Follow-up | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | 이광재 | - |
dc.contributor.googleauthor | 한광협 | - |
dc.contributor.googleauthor | 전재윤 | - |
dc.contributor.googleauthor | 문영명 | - |
dc.contributor.googleauthor | 이상인 | - |
dc.contributor.googleauthor | 박인서 | - |
dc.contributor.googleauthor | 김호근 | - |
dc.contributor.googleauthor | 박찬일 | - |
dc.contributor.googleauthor | 오희철 | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A01710 | - |
dc.relation.journalcode | J02015 | - |
dc.identifier.eissn | 2233-6869 | - |
dc.contributor.alternativeName | Kim, Hogeun | - |
dc.contributor.affiliatedAuthor | 김호근 | - |
dc.contributor.affiliatedAuthor | 박찬일 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 343 | - |
dc.citation.endPage | 351 | - |
dc.identifier.bibliographicCitation | Korean Journal of Gastroenterology, Vol.29(3) : 343-351, 1997 | - |
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