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자궁내막암조직에서 c-erbB-2 암유전자 단백산물과 예후인자와의 연관성
DC Field | Value | Language |
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dc.contributor.author | 김세광 | - |
dc.contributor.author | 김영태 | - |
dc.date.accessioned | 2020-07-03T17:32:51Z | - |
dc.date.available | 2020-07-03T17:32:51Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0494-4755 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177633 | - |
dc.description.abstract | The c-erbB-2 oncogene encodes a 185,00 dalton transmembrane glycoportein with tyrosine kinase activity, and the aberrant overexpression of which has been implicated in the indution of a malignat phenotype. Overexpression of the c-erbB-2 has been found in many human adenocarcinomas, especially mammarian and ovarian carcinomas, and that is associated with poor prognosis. We used an enzyme-linked immunosorbent assay(ELISA) to explore the relationship between c-erbB-2 oncoprotein and prognostic factors of endmetrial cancer and analyzed the tissued form the 24patients with endometiral cancer and 10 control cases. patinens with endometrial cancer were found to bave 20% of c-erbB-2 oncoprotein overexpression rate and signficiantly higher c-erbB-2 median oncoprotein expression than conterol C-erbB-2 oncoprotein overexpression showed no statistically significant association with known prognostic factors including stage, grade, histologic cell type, myometrial invasion and lymph node metastases, although the c-erbB-2 oncoprotein overexpression rate was increased by stage, and was higher in lymph node metastatic group than in confined to the uterus goup. High c-erbB-2 oncoprotein overexpression was correlated with absence of estrogen receptor (Rs=-0.46, p=0.047) and progestreone receptor (Rs=-0.57, p=0.045), further studies are needed to determine the significance of the c-erbB-2 everexpression in endometrial cancer. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | Korean | - |
dc.publisher | 대한산부인과학회 | - |
dc.relation.isPartOf | Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 자궁내막암조직에서 c-erbB-2 암유전자 단백산물과 예후인자와의 연관성 | - |
dc.title.alternative | Correlation between Expression of C-erbB2 Oncoprotein and the Prognostic Factors in Endometrial Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.googleauthor | 김영태 | - |
dc.contributor.googleauthor | 윤혜정 | - |
dc.contributor.googleauthor | 김동현 | - |
dc.contributor.googleauthor | 이학천 | - |
dc.contributor.googleauthor | 김세광 | - |
dc.contributor.googleauthor | 김재욱 | - |
dc.contributor.localId | A00601 | - |
dc.contributor.localId | A00729 | - |
dc.relation.journalcode | J02075 | - |
dc.identifier.url | http://kiss.kstudy.com/thesis/thesis-view.asp?key=1856309 | - |
dc.contributor.alternativeName | Kim, Sei Kwang | - |
dc.contributor.affiliatedAuthor | 김세광 | - |
dc.contributor.affiliatedAuthor | 김영태 | - |
dc.citation.volume | 40 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 847 | - |
dc.citation.endPage | 855 | - |
dc.identifier.bibliographicCitation | Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지), Vol.40(4) : 847-855, 1997 | - |
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