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흰쥐 정관 운동에 대한 Nitric Oxide의 역할
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최영득 | - |
dc.date.accessioned | 2020-07-03T17:32:18Z | - |
dc.date.available | 2020-07-03T17:32:18Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0494-4747 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177625 | - |
dc.description.abstract | Many physiologic studies have been carried out to identify the neurotransmitters involved in regulating the motility of the smooth muscle in the vas deferens, but the transmitter of a nonadrenergic and non-cholinergic inhibitory nerves has not been clearly identified. We investigated the role of nitric oxide in response to sympathetic motor activity in the rat vas deferens. 1. Nitroprusside and L-NAME had neither contractile nor relaxing effects directly. On the stabilized muscle strips of rat vas deferens, norepinephrine induced a phasic contraction for 10 seconds followed by the sustained tonic contraction. The phasic contraction of norepinephrine was increased by the pretreatment of nitroprusside(p>0.05) and decreased by LNAME(p<0.01). This tonic contraction was decreased dose-dependently by the pretreatment of nitroprusside(p<0.01), and increased by L-NAME(p<0.01). On the muscle strips of rat vas deferens, submaximally precontracted with norepinephrine, nitroprusside potentiated the contraction, followed by the delayed, sustained relaxation, which was blocked by L-NAME. 2. On the muscle strips of rat vas deferens, electrical field stimulation induced an initial phasic contraction for 2-3 seconds, followed by the tonic contraction, which was blocked by L-NAME dose-dependently. The phasic contraction of electrical field stimulation was increased by the pretreatment of nitroprusside(p>0.05) and decreased by L-NAME(p<0.01). This tonic contraction was decreased by the pretreatment of nitroprusside dose-dependently(p<0.01), and increased by L-NAME(.p<0.01). With these results, nitric oxide has the excitatory effect at the phasic contraction, and the inhibitory effect at the tonic contraction in response to sympathetic motor activity in the rat vas deferens partially. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한비뇨기과학회 | - |
dc.relation.isPartOf | Korean Journal of Urology (대한비뇨기과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 흰쥐 정관 운동에 대한 Nitric Oxide의 역할 | - |
dc.title.alternative | Role of Nitric Oxide in the Motor Activity of Rat Vas Deferens | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | 이택 | - |
dc.contributor.googleauthor | 최영득 | - |
dc.contributor.googleauthor | 이무상 | - |
dc.contributor.localId | A04111 | - |
dc.relation.journalcode | J02135 | - |
dc.contributor.alternativeName | Choi, Young Deuk | - |
dc.contributor.affiliatedAuthor | 최영득 | - |
dc.citation.volume | 38 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 21 | - |
dc.citation.endPage | 27 | - |
dc.identifier.bibliographicCitation | Korean Journal of Urology (대한비뇨기과학회지), Vol.38(1) : 21-27, 1997 | - |
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