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Sjögren 증후군의 임상적 고찰
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박용범 | - |
dc.contributor.author | 이수곤 | - |
dc.date.accessioned | 2020-07-03T17:26:54Z | - |
dc.date.available | 2020-07-03T17:26:54Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 1226-8070 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177556 | - |
dc.description.abstract | Objectives : To investigate the clinical characteristics of Sjögren's syndrome (SS). Methods : We. retrospectively reviewed 59 patients with SS in the period from January 1986 to January 1997. European Epidemiology Center criteria was used to diagnose SS. Results : Thirty-one primary SS and 28 secondary SS patients were included in this study. There were 57 females and 2 males, the mean age was 45.2+12.3 years (24 to 70 years). Patients with secondary SS were associated with rheumatoid arthritis (n=10), systemic lupus erythematosus (n=7), scleroderma (n=5), mixed connective tissue disease (n=3), and myositis (n=3). The common presenting symptoms were dry mouth in 92% and dry eyes in 90% of patients. Other symptom and signs included fatigue (27%), lymphadenopathy (22%) and parotid gland swelling (10%). The commonly presented autoantibodies were antinuclear antibody (83%) and rheumatoid factor (57%). Anti-Ro was positive in 49% (25/51) and anti-La in 37% (19/51). Anti-La positivity was significantly higher in primary SS (52%) compared to secondary SS (21%) (p<0.05). Schirmer test was positive in 98% (44/45), salivary radioscintigraphy in 74%(25/34), and lower lip biopsy in 47% (16/34). Extraglandular manifestations, such as Raynaud's phenomenon, vasculitis, glomerulonephritis, vaginal dryness, renal tubular acidosis, and primary biliary cirrhosis, were more frequently presented in primary SS compared to secondary SS (p<0. 05). Conclusion : The sex, age, and clinical manifestation of primary SS were similar with secondary SS, but extraglandular manifestations and anti-La antibody positivity were more frequent in primary SS. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한류마티스학회 | - |
dc.relation.isPartOf | Journal of the Korean Rheumatism Association (대한류마티스학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Sjögren 증후군의 임상적 고찰 | - |
dc.title.alternative | Clinical Analysis of Sjögren's Syndrome. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 이충원 | - |
dc.contributor.googleauthor | 이원기 | - |
dc.contributor.googleauthor | 이지수 | - |
dc.contributor.googleauthor | 이찬희 | - |
dc.contributor.googleauthor | 송창호 | - |
dc.contributor.googleauthor | 서창희 | - |
dc.contributor.googleauthor | 박용범 | - |
dc.contributor.googleauthor | 이수곤 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02889 | - |
dc.relation.journalcode | J01847 | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | 박용범 | - |
dc.contributor.affiliatedAuthor | 이수곤 | - |
dc.citation.volume | 4 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 139 | - |
dc.citation.endPage | 146 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Rheumatism Association (대한류마티스학회지), Vol.4(2) : 139-146, 1997 | - |
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