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한국에서 분리된 Klebsiella pneumoniae가 생성하는 Extended-spectrum β-lactamase의 유형 및 특징
DC Field | Value | Language |
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dc.contributor.author | 이경원 | - |
dc.date.accessioned | 2020-07-03T17:21:36Z | - |
dc.date.available | 2020-07-03T17:21:36Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0368-6221 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177471 | - |
dc.description.abstract | BACKGROUND: Extended-spectrum beta-lactamases (ESBLs) are plasmid-mediated enzymes that confer resistance to oxyimino-beta-lactams such as cefotaxime, ceftazidime, and aztreonam, antibiotics that were designed to be effective against strains producing known plasmid-determined beta-lactamases. METHODS: Fifty-seven isolates of ESBL producing K. pneumoniae which were collected from 3 hospitals in Korea were characterized. They either transferred ceftazidime resistance or showed clavulanic acid enhancement of oxyimino-beta-lactam susceptibility. Beta-lactamase production by clinical isolates and transconjugants were characterized by isoelectric focusing and MIC values of oxyimino-beta-lactam were determined by agar dilution method. We performed PCR and RFLP for further characterization of TEM-type ESBLs. RESULTS: The results showed that SHV-type ESBLs, especially SHV-5 and SHV-2 predominated, but TEM-4 and plasmid- mediated AmpC beta-lactamases (pI 8.0 and pI 8.4) were present as well: SHV-5, 26; SHV-2, 12; TEM-4, 9; plasmid-mediated AmpC type beta-lactamase (pI 8.0), 4; plasmid-mediated AmpC type beta-lactamase (pI 8.4), 1. Two isolates produced both TEM-4 and SHV-5, which showed higher MIC50 of cefotaxime, ceftazidime and aztreonam than those in the isolates producing TEM-4 or SHV-5. Three isolates produced both plasmid-mediated AmpC type beta-lactamases and other ESBLs, each one of TEM-4, SHV-2 and SHV-5. All of the isolates showed high resistance to cefoxitin, cefotaxime, ceftazidime and aztreonam. CONCLUSION: With these results we conclude that SHV-type ESBLs outnumber and plasmid-mediated AmpC type beta-lactamases are present in high frequency in Korea. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한감염학회 | - |
dc.relation.isPartOf | Korean Journal of Infectious Diseases (감염) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 한국에서 분리된 Klebsiella pneumoniae가 생성하는 Extended-spectrum β-lactamase의 유형 및 특징 | - |
dc.title.alternative | Characterization of Extended-spectrum ?-lactamases in Klebsiella pneumoniae Isolated in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | 배현주 | - |
dc.contributor.googleauthor | 김정민 | - |
dc.contributor.googleauthor | 권영미 | - |
dc.contributor.googleauthor | 이경원 | - |
dc.contributor.googleauthor | 정윤섭 | - |
dc.contributor.googleauthor | 김의종 | - |
dc.contributor.googleauthor | 조동택 | - |
dc.contributor.localId | A02649 | - |
dc.relation.journalcode | J02040 | - |
dc.contributor.alternativeName | Lee, Kyungwon | - |
dc.contributor.affiliatedAuthor | 이경원 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 93 | - |
dc.citation.endPage | 103 | - |
dc.identifier.bibliographicCitation | Korean Journal of Infectious Diseases (감염), Vol.29(2) : 93-103, 1997 | - |
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