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Granzyme B immunoreactivity in T/natural killer cell lymphomas

DC FieldValueLanguage
dc.contributor.author윤주헌-
dc.date.accessioned2020-07-03T17:19:48Z-
dc.date.available2020-07-03T17:19:48Z-
dc.date.issued1997-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/177447-
dc.description.abstractGranzyme B is one of the serine proteases expressed in natural killer (NK) cells and activated cytotoxic T-lymphocytes. To evaluate the usefulness of granzyme B immunoreactivity in the diagnosis of T/NK-cell lymphoma, we studied 69 cases of lymphomas occurring in the upper aerodigestive tract by paraffin-section immunohistochemistry using a commercially available monoclonal antibody to granzyme B (GrB-7). All 19 cases of T/NK-cell lymphomas defined by the expression of CD56 (NHK-1) and one or both T-cell markers (polyclonal CD3 and CD45RO) expressed granular cytoplasmic granzyme B immunoreactivity. Two out of 9 cases of T-cell lymphomas showing no CD56 expression demonstrated strong granzyme B immunoreactivity. No tumor cells among 39 cases of B-cell diffuse large cell lymphomas and 2 cases of null cell diffuse large cell lymphomas were immunoreactive for granzyme B, however a few scattered granzyme B-positive reactive small lymphoid cells were consistently observed. Based on its sensitivity in this study as well as its reactivity in routinely processed tissue sections, even without heat-induced epitope retrieval technique, monoclonal antibody to granzyme B (GrB-7) can be applied as a useful marker in the diagnosis of T/NK-cell lymphomas in conjunction with CD56.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHChild-
dc.subject.MESHFemale-
dc.subject.MESHGranzymes-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHKiller Cells, Natural/pathology*-
dc.subject.MESHLymphoma/enzymology*-
dc.subject.MESHLymphoma/pathology*-
dc.subject.MESHLymphoma, T-Cell/enzymology*-
dc.subject.MESHLymphoma, T-Cell/pathology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHSerine Endopeptidases/metabolism*-
dc.titleGranzyme B immunoreactivity in T/natural killer cell lymphomas-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학교실)-
dc.contributor.googleauthorMin Sun Cho-
dc.contributor.googleauthorMi Kyung Lee-
dc.contributor.googleauthorWoo Ick Yang-
dc.contributor.googleauthorJoo Heon Yoon-
dc.identifier.doi10.3349/ymj.1997.38.5.285-
dc.contributor.localIdA02604-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid9409191-
dc.contributor.alternativeNameYoon, Joo Heon-
dc.contributor.affiliatedAuthor윤주헌-
dc.citation.volume38-
dc.citation.number5-
dc.citation.startPage285-
dc.citation.endPage293-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.38(5) : 285-293, 1997-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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