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EBV-elicited familial hemophagocytic lymphohistiocytosis

Authors
 Hyun Sang Cho  ;  Young Nyun Park  ;  Chuhl Joo Lyu  ;  Sae Myung Park  ;  Seung Hwan Oh  ;  Chang Hyun Yang  ;  Woo Ick Yang  ;  Kir Young Kim 
Citation
 YONSEI MEDICAL JOURNAL, Vol.38(4) : 245-248, 1997 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
1997
MeSH
Child, Preschool ; Female ; Herpesviridae Infections/complications* ; Herpesvirus 4, Human* ; Histiocytosis, Non-Langerhans-Cell/genetics* ; Histiocytosis, Non-Langerhans-Cell/virology* ; Humans ; Infant ; Male ; Tumor Virus Infections/complications*
Abstract
Familial hemophagocytic lymphohistiocytosis (FHL) is a rapidly fatal illness, usually encountered in infancy, characterized by fever, hepatosplenomegaly, pancytopenia, and central nervous system involvement. Microscopic examination of tissue shows a non-malignant lymphohistiocytic infiltrate, with prominent erythrophagocytosis. FHL is an autosomal recessive hereditary disorder but may develop secondarily to other conditions such as immunosuppression, malignancies, fat overload and certain infections. We recently experienced a case of siblings developing FHL, which may be associated with EBV infection.
Files in This Item:
T199701561.pdf Download
DOI
10.3349/ymj.1997.38.4.245
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177433
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