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Post-transplantation diabetes is better controlled after conversion from prednisone to deflazacort: prospective trial in renal transplants

DC FieldValueLanguage
dc.contributor.author김유선-
dc.contributor.author임승길-
dc.contributor.author임승길-
dc.date.accessioned2020-07-03T17:17:48Z-
dc.date.available2020-07-03T17:17:48Z-
dc.date.issued1997-
dc.identifier.issn0934-0874-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/177418-
dc.description.abstractIt is well known that long-term use of steroids plays a decisive role in the development of glucose intolerance and diabetes mellitus (DM). Deflazacort, an oxazoline derivative of prednisolone, has been introduced as a potential substitute for conventional steroids in order to ameliorate glucose intolerance. We initiated a randomized study of conversion from prednisone to deflazacort in kidney transplantation (Tx) recipients presenting with pre-Tx or post-Tx DM to ascertain whether or not the switch to deflazacort would ameliorate the diabetic state. Forty-two recipients in the conversion group were compared with 40 patients on prednisone (the control group) in a prospective manner. The dose reduction of insulin or oral blood glucose-lowering agents, the adequacy of glucose control, and the development of side effects were the criteria for evaluating outcome. In the conversion group, patients were switched to a deflazacort at a dose ratio of 6 mg deflazacort to 5 mg prednisone. During the mean follow-up period of 13.2 months, neither graft dysfunction nor acute rejection developed in the conversion group. Improvement in blood glucose control in the conversion group was noted. When the conversion group was stratified into pre- or post-Tx DM, promising effects were clearly evident in the post-Tx DM patients. More than 50% dose reduction of blood glucose-lowering agents was possible in 42.3% of post-Tx DM patients. In conclusion, it was readily possible to control blood glucose better in post-Tx DM recipients without seriously affecting the immunosuppressive activity after conversion to deflazacort.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBlackwell Pub.-
dc.relation.isPartOfTRANSPLANT INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHBlood Glucose/metabolism-
dc.subject.MESHBody Weight-
dc.subject.MESHDiabetes Mellitus/drug therapy*-
dc.subject.MESHFemale-
dc.subject.MESHGlycated Hemoglobin A/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHImmunosuppressive Agents/therapeutic use*-
dc.subject.MESHKidney Transplantation*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrednisone/therapeutic use*-
dc.subject.MESHPregnenediones/therapeutic use*-
dc.subject.MESHProspective Studies-
dc.titlePost-transplantation diabetes is better controlled after conversion from prednisone to deflazacort: prospective trial in renal transplants-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorYu Seun Kim-
dc.contributor.googleauthorMyoung Soo Kim-
dc.contributor.googleauthorSoon II Kim-
dc.contributor.googleauthorKiil Park-
dc.contributor.googleauthorSeung Kil Lim-
dc.contributor.googleauthorHo Yung Lee-
dc.contributor.googleauthorDae Suk Han-
dc.identifier.doi10.1007/s001470050041-
dc.contributor.localIdA00785-
dc.contributor.localIdA03375-
dc.contributor.localIdA03375-
dc.contributor.localIdA03375-
dc.contributor.localIdA03375-
dc.relation.journalcodeJ02753-
dc.identifier.eissn1432-2277-
dc.identifier.pmid9163859-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1111/j.1432-2277.1997.tb00685.x?sid=vendor%3Adatabase-
dc.contributor.alternativeNameKim, Yu Seun-
dc.contributor.affiliatedAuthor김유선-
dc.contributor.affiliatedAuthor임승길-
dc.contributor.affiliatedAuthor임승길-
dc.contributor.affiliatedAuthor임승길-
dc.contributor.affiliatedAuthor임승길-
dc.citation.volume10-
dc.citation.number3-
dc.citation.startPage197-
dc.citation.endPage201-
dc.identifier.bibliographicCitationTRANSPLANT INTERNATIONAL, Vol.10(3) : 197-201, 1997-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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