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Spread of the Serotype 23F Multidrug-Resistant Streptococcus pneumoniae Clone to South Korea

Authors
 AGAPITO TARASI  ;  YUNSOP CHONG  ;  KYUNGWON LEE  ;  ALEXANDER TOMASZ 
Citation
 MICROBIAL DRUG RESISTANCE, Vol.3(1) : 105-109, 1997 
Journal Title
 MICROBIAL DRUG RESISTANCE 
ISSN
 1076-6294 
Issue Date
1997
MeSH
DNA Fingerprinting ; DNA, Bacterial/analysis ; DNA, Bacterial/biosynthesis ; DNA, Bacterial/genetics ; Drug Resistance, Multiple/genetics ; Electrophoresis, Polyacrylamide Gel ; Humans ; Korea ; Penicillin Resistance ; Pneumococcal Infections/genetics* ; Pneumococcal Infections/transmission* ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/genetics*
Abstract
Thirty-eight antibiotic-resistant isolates of Streptococcus pneumoniae recovered in a hospital in Seoul, Korea, between February 1990 and March 1992 were analyzed for serotype, antibiotic susceptibility patterns, and chromosomal relatedness using pulsed-field gel electrophoretic (PFGE) analysis of SmaI chromosomal digests. Most of the isolates were from sputum samples, and a few strains were from otitis media and meningitis. The great majority of isolates (34 of 38, or 89%) were multiresistant, sharing virtually identical, elevated minimal inhibitory concentration (MIC) values (microgram/ml) for penicillin (1-2), chloramphenicol (12-25), tetracycline (25-30), and sulfamethoxazole/trimethoprim (> 100). Twenty of the isolates were also resistant to erythromycin, and all isolates were also considered to be resistant to ceftriaxone and cefotaxime (1-2) according to the new breakpoint definitions. The most frequent serotypes were 23F (17 of 38) and 19F(14 of 38); 2 belonged to serotype 15B and 1 of 24F. Of the remaining 4 isolates (2 serotype 3, 1 type 6B, and 1 type 9V) all were resistant to tetracycline and sulfamethoxazole/trimethoprim and with the exception of 1 of the type 3 strains, were also resistant to chloramphenicol. Eleven of the 14 serotype 19F isolates shared a relatively homogeneous PFGE pattern, which was indistinguishable from the PFGE pattern shown by most (12 of 17) of the 23F isolates. The PFGE pattern of these 19F and 23F isolates was also indistinguishable from the PFGE pattern shown by representative multiresistant capsular type 23F isolates from Croatia, Portugal, and New York City and the findings document the extensive geographic spread of this multidrug-resistant S. pneumoniae clone. The data also suggests in vivo capsular transformation of the multiresistant clone from serotype 23F to serotype 19F.
Full Text
https://www.liebertpub.com/doi/abs/10.1089/mdr.1997.3.105
DOI
10.1089/mdr.1997.3.105
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177378
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