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Inhibition of Neointimal Proliferation of Rat Carotid Artery by Sulodexide

Authors
 Hyun-Young Park  ;  Seokmin Kang  ;  Geon-Young Kim  ;  Yangsoo Jang  ;  Hyuck-Moon Kwon  ;  Won-Heum Shim  ;  Seung-Yeon Cho  ;  Sang-Ho Cho 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.12(3) : 210-214, 1997 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
1997
MeSH
Angioplasty, Balloon/adverse effects ; Animals ; Carotid Arteries ; Cell Division/drug effects ; Glycosaminoglycans/pharmacology* ; Growth Inhibitors/pharmacology* ; Male ; Muscle, Smooth, Vascular/drug effects* ; Rats ; Rats, Sprague-Dawley ; Thrombosis/etiology ; Thrombosis/prevention & control
Abstract
Sulodexide, a glycosaminoglycan-containing compound, is known to have an antiproliferative effect on vascular smooth-muscle cells, in vitro, as well as antithrombotic and fibrinolytic effects. But there are few reports about the effect of neointimal proliferation in vivo. In this study, we examined whether Sulodexide was effective in the inhibition of neointimal proliferation after vascular injury. Ten-week-old Sprague-Dawley rats were subjected to vascular injury by endothelial denudation of the common carotid artery by using a balloon catheter. They were then allocated randomly into a control group (saline 2 ml for 3 days, and then 1 ml for 18 days, IM) and a treated group (Sulodexide 10 mg/kg/day for 3 days, and then 4 mg/kg/day for 18 days, IM). Three weeks after vascular injury, we analyzed the neointimal proliferation using morphometry. The neointimal proliferation was significantly reduced in the treated group compared to the control group (Ratio of neointimal area to medial area; 118.39 +/- 6.80% in the treated group, 177.25 +/- 17.25% in the control group). This result showed that Sulodexide might be effective in reducing the rate of restenosis after balloon angioplasty.
Files in This Item:
T199703045.pdf Download
DOI
10.3346/jkms.1997.12.3.210
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177336
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