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Nitrous oxide synthase expression in placenta of preeclampsia

Authors
 Chung No Lee  ;  Sung Woon Chang  ;  Nam Hoon Cho  ;  Sang Ho Cho 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.12(6) : 532-538, 1997 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
1997
MeSH
Adult ; Endothelium/enzymology ; Female ; Fetus/chemistry ; Fetus/enzymology ; Gestational Age ; Humans ; Immunohistochemistry ; Nitric Oxide Synthase/analysis ; Nitric Oxide Synthase/metabolism* ; Placenta/chemistry ; Placenta/enzymology* ; Pre-Eclampsia/enzymology* ; Pregnancy ; Tissue Distribution
Abstract
To compare the expression of endothelial nitrous oxide synthase (e-NOS), which plays a major role in vasoconstriction, in preeclampsia with that in the normotensive placenta and to identify whether or not e-NOS actually influences the pathogenesis of preeclampsia, we have studied the distribution and intensity of the endothelial isoform of NOS expression in preeclampsia (n = 121) and normal (n = 14) pregnancies. Archival paraffin-embedded tissues were immunostained with a polyclonal e-NOS antibody. E-NOS was stained predominantly in the endothelial cells of the umbilical cord and along the surface of the villi, especially within the cytoplasms of the syncytiotrophoblasts with a granular and punctuated pattern, but not in the trophoblastic island or in the intravillous capillaries. The degree of e-NOS expression in pregnancy-induced hypertension (PIH) was significantly lower than in normotensive placenta, and moreover in the patients lacking abruptio. The expression of e-NOS in preeclampsia has some correlation with patient age. In conclusion, the degree of e-NOS expression in cotyledon from PIH is far less than from control, it means a kind of hemodynamic alteration of the fetoplacental circulation in preeclampsia.
Files in This Item:
T199702536.pdf Download
DOI
10.3346/jkms.1997.12.6.532
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177331
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