Cited 2 times in
Sry gene detection in gonads of intersex patients using FISH
DC Field | Value | Language |
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dc.contributor.author | 조남훈 | - |
dc.contributor.author | 한상원 | - |
dc.date.accessioned | 2020-07-03T17:11:03Z | - |
dc.date.available | 2020-07-03T17:11:03Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177330 | - |
dc.description.abstract | A candidate gene for sex determination was localized within a 35 kb region of the Y chromosome immediately adjacent to the pseudoautosomal boundary. Here, we describe a study of Sry detection in the gonads of intersex patients including 5 male pseudohermaphrodite (MPH), 4 XX true hermaphrodite (TH) and each 1 mixed gonadal dysgenesis (MGD) and XX sex reversal, and in the clitoris of 3 female pseudohermaphrodite (FPH) by fluorescent in situ hybridization (FISH). Sry gene was observed in all cases of MPH and each case of MGD and sex reversal in contrast to bare expression in all cases of FPH and most of TH. To our knowledge, the Sry gene itself functions testicular determination in almost all intersex cases except true hermaphrodite, a distinguished type of intersex in a different pathogenesis. In addition, FISH might be useful to detect the translocated Sry gene and localize the signal with ease. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | 대한의학회(The Korean Academy of Medical Sciences) | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Clitoris/metabolism | - |
dc.subject.MESH | DNA-Binding Proteins/genetics* | - |
dc.subject.MESH | Disorders of Sex Development/genetics* | - |
dc.subject.MESH | Disorders of Sex Development/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gonads/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Situ Hybridization, Fluorescence | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Nuclear Proteins* | - |
dc.subject.MESH | Sex Differentiation/genetics* | - |
dc.subject.MESH | Sex-Determining Region Y Protein | - |
dc.subject.MESH | Transcription Factors* | - |
dc.title | Sry gene detection in gonads of intersex patients using FISH | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Nam Hoon Cho | - |
dc.contributor.googleauthor | Sang Won Han | - |
dc.contributor.googleauthor | Mahn Jun Ha | - |
dc.identifier.doi | 10.3346/jkms.1997.12.3.204 | - |
dc.contributor.localId | A03812 | - |
dc.contributor.localId | A04285 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 9250915 | - |
dc.contributor.alternativeName | Cho, Nam Hoon | - |
dc.contributor.affiliatedAuthor | 조남훈 | - |
dc.contributor.affiliatedAuthor | 한상원 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 204 | - |
dc.citation.endPage | 209 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.12(3) : 204-209, 1997 | - |
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