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Relationship between Loss of Heterozygosity of Tumor Suppressor Genes and Histologic Differentiation in Hepatocellular Carcinoma

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dc.contributor.author김호근-
dc.contributor.author박찬일-
dc.date.accessioned2020-07-03T17:06:30Z-
dc.date.available2020-07-03T17:06:30Z-
dc.date.issued1997-
dc.identifier.issn0008-543X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/177276-
dc.description.abstractBACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common human tumors in Asia and Africa. The molecular genetic changes involving both protooncogenes and tumor suppressor genes are known to be involved in hepatocarcinogenesis, but the roles of the known tumor suppressor genes in hepatocarcinogenesis are not fully elucidated. In this study, the authors analyzed the loss of heterozygosity (LOH) of known tumor suppressor genes in HCC and evaluated the relationship between LOH of tumor suppressor genes and clinicopathologic features. METHODS: The authors assessed the LOH of the 10 known tumor suppressor genes (VHL, APC, EXT1, WT1, Rb1, p53, BRCA1, nm23, DPC4, and DCC) with microsatellite markers in 29 consecutively resected HCC specimens. RESULTS: The authors found frequent LOH of tumor suppressor genes in HCC. Twenty five of 29 cases (86%) had LOH of tumor suppressor genes and 17 cases (59%) had LOHs involving 2-4 tumor suppressor genes. Among the tumor suppressor genes, frequent LOH was noted in the p53 (66%), Rb1 (33%), EXT1 (33%), and APC (20%) genes. LOH of the p53 gene and multiple LOH of the tumor suppressor genes were more frequent in poorly differentiated HCCs (P = 0.02). CONCLUSIONS: The LOH of tumor suppressor genes is frequent in HCCs and LOH of the p53 gene and accumulated LOHs are related to poorly differentiated HCC. Abnormalities of the p53 gene or the accumulated abnormalities of the tumor suppressor genes may play a role in the aggressive progression of HCC.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-
dc.relation.isPartOfCANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAlleles-
dc.subject.MESHCarcinoma, Hepatocellular/genetics*-
dc.subject.MESHCarcinoma, Hepatocellular/pathology-
dc.subject.MESHCell Differentiation/genetics-
dc.subject.MESHFemale-
dc.subject.MESHGene Deletion-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHGenes, Tumor Suppressor/genetics*-
dc.subject.MESHHeterozygote-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms/genetics*-
dc.subject.MESHLiver Neoplasms/pathology-
dc.subject.MESHMale-
dc.subject.MESHMicrosatellite Repeats-
dc.subject.MESHMiddle Aged-
dc.titleRelationship between Loss of Heterozygosity of Tumor Suppressor Genes and Histologic Differentiation in Hepatocellular Carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorZhe Piao-
dc.contributor.googleauthorHoguen Kim-
dc.contributor.googleauthorBong Kyun Jeon-
dc.contributor.googleauthorWoo Jung Lee-
dc.contributor.googleauthorChanil Park-
dc.contributor.localIdA01183-
dc.contributor.localIdA01710-
dc.relation.journalcodeJ00434-
dc.identifier.eissn1097-0142-
dc.identifier.pmid9307185-
dc.identifier.urlhttps://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/(SICI)1097-0142(19970901)80:5%3C865::AID-CNCR6%3E3.0.CO;2-K-
dc.contributor.alternativeNameKim, Hogeun-
dc.contributor.affiliatedAuthor김호근-
dc.contributor.affiliatedAuthor박찬일-
dc.citation.volume80-
dc.citation.number5-
dc.citation.startPage865-
dc.citation.endPage872-
dc.identifier.bibliographicCitationCANCER, Vol.80(5) : 865-872, 1997-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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