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Correlation between K-ras gene mutation and prognosis of patients with nonsmall cell lung carcinoma
DC Field | Value | Language |
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dc.contributor.author | 김주항 | - |
dc.contributor.author | 노재경 | - |
dc.contributor.author | 정경영 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 조재용 | - |
dc.date.accessioned | 2020-07-03T17:06:27Z | - |
dc.date.available | 2020-07-03T17:06:27Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0008-543X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177275 | - |
dc.description.abstract | BACKGROUND: Mutations at codons 12, 13, and 61 of the three ras genes, H-ras, K-ras, and N-ras, convert these genes into active oncogenes. It appears that ras gene mutations can be found in a variety of tumor types. The purpose of this study was to evaluate the clinical significance of K-ras gene mutation in nonsmall cell lung carcinoma (NSCLC). METHODS: The authors analyzed 58 NSCLC patients for mutations at codons 12, 13, and 61 of the K-ras gene and correlated the findings with the tumor stage and patient survival. Polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and the direct nucleotide sequencing method were used to detect mutations after amplification of ras specific sequences by PCR. RESULTS: Fourteen mutations (24%) of ras genes were found, all at codon 12 of the K-ras gene. GGT to GAT transition was the predominant mutational pattern. There was a significant association between K-ras mutation and the tumor stage (i.e., the higher the stage, the higher the mutation rate) (P = 0.014). Using univariate analysis, the presence of K-ras mutation in paraffin embedded tissue from patients who received treatment with curative intent was associated with a shorter survival (P = 0.039). The median survival duration for patients with or without K-ras mutation was 9 and 30 months, respectively. The Cox proportional hazards model also predicted a higher risk for patients with K-ras mutations (P = 0.047). CONCLUSIONS: K-ras mutations, present in a subset of NSCLC, are associated with tumor progression and shortened patient survival. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley | - |
dc.relation.isPartOf | CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/genetics* | - |
dc.subject.MESH | DNA Probes | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genes, ras/genetics* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung Neoplasms/genetics* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mutation* | - |
dc.subject.MESH | Polymerase Chain Reaction | - |
dc.subject.MESH | Polymorphism, Single-Stranded Conformational | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Survival Analysis | - |
dc.title | Correlation between K-ras gene mutation and prognosis of patients with nonsmall cell lung carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jae Yong Cho | - |
dc.contributor.googleauthor | Joo Hang Kim | - |
dc.contributor.googleauthor | Yi Hyeong Lee | - |
dc.contributor.googleauthor | Kyung Young Chung | - |
dc.contributor.googleauthor | Sung Kyu Kim | - |
dc.contributor.googleauthor | Soo Jung Gong | - |
dc.contributor.googleauthor | Nae Choon You | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.contributor.googleauthor | Jae Kyung Roh | - |
dc.contributor.googleauthor | Byung Soo Kim | - |
dc.identifier.doi | 10.1002/(sici)1097-0142(19970201)79:3<462::aid-cncr6>3.0.co;2-k | - |
dc.contributor.localId | A00945 | - |
dc.contributor.localId | A01290 | - |
dc.contributor.localId | A03571 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A03899 | - |
dc.relation.journalcode | J00434 | - |
dc.identifier.eissn | 1097-0142 | - |
dc.identifier.pmid | 9028355 | - |
dc.identifier.url | https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/(sici)1097-0142(19970201)79:3%3C462::aid-cncr6%3E3.0.co;2-k | - |
dc.contributor.alternativeName | Kim, Joo Hang | - |
dc.contributor.affiliatedAuthor | 김주항 | - |
dc.contributor.affiliatedAuthor | 노재경 | - |
dc.contributor.affiliatedAuthor | 정경영 | - |
dc.contributor.affiliatedAuthor | 정현철 | - |
dc.contributor.affiliatedAuthor | 조재용 | - |
dc.citation.volume | 79 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 462 | - |
dc.citation.endPage | 467 | - |
dc.identifier.bibliographicCitation | CANCER, Vol.79(3) : 462-467, 1997 | - |
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