Cited 15 times in
Difference in the expression of Fas/Fas-ligand and the lymphocyte subset reconstitution according to the occurrence of acute GVHD
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 민유홍 | - |
dc.date.accessioned | 2020-07-03T17:05:52Z | - |
dc.date.available | 2020-07-03T17:05:52Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0268-3369 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177269 | - |
dc.description.abstract | Acute graft-versus-host disease (aGVHD) remains a major barrier to a wider application of allogeneic bone marrow transplantation (BMT). Although this complication is mainly dependent on donor-derived T lymphocytes, very little information is available concerning the mechanism of lethality. In this study, we investigated both the expression of Fas/Fas-ligand (FasL) and lymphocyte subset reconstitution in patients who underwent HLA-matched related allogeneic BMT (n = 16) and normal donors (n = 10), and several distinct features were observed. First, the reconstitutions of CD3+ and CD56+ cells were different between the aGVHD+ and aGVHD- group. In particular, the percentage of CD3-CD56+ cells was significantly decreased in patients with aGVHD (P < 0.01). Second, the expansion of CD8+ (P = 0.01) and CD8+ CD28- T cells (P = 0.03) was a characteristic finding in patients with aGVHD. Finally, we found that the percentages of Fas+CD8+, Fas+HLA-DR+ and FasL+ CD8+ cells were significantly increased. Fas antigen was highly coexpressed on most of the lymphocyte subsets, especially on CD8+ cells (P < 0.01), and also, significantly higher coexpression of FasL on CD8+ cells was found in patients with aGVHD (P < 0.01). In summary, an increase in the percentage of CD8+ cells which express Fas and its ligand in patients with aGVHD after BMT points to a possible role for the Fas/FasL pathway in the effector phase of aGVHD. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | BONE MARROW TRANSPLANTATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Acute Disease | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Bone Marrow Transplantation/adverse effects | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes/immunology | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes/metabolism | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes/pathology* | - |
dc.subject.MESH | Fas Ligand Protein | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation | - |
dc.subject.MESH | Graft Survival | - |
dc.subject.MESH | Graft vs Host Disease/blood | - |
dc.subject.MESH | Graft vs Host Disease/immunology | - |
dc.subject.MESH | Graft vs Host Disease/pathology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunophenotyping | - |
dc.subject.MESH | Leukemia/therapy | - |
dc.subject.MESH | Leukocyte Count | - |
dc.subject.MESH | Lymphocyte Count | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Membrane Glycoproteins/biosynthesis* | - |
dc.subject.MESH | Membrane Glycoproteins/genetics | - |
dc.subject.MESH | T-Lymphocyte Subsets/immunology | - |
dc.subject.MESH | T-Lymphocyte Subsets/metabolism | - |
dc.subject.MESH | T-Lymphocyte Subsets/pathology* | - |
dc.subject.MESH | T-Lymphocytes, Cytotoxic/immunology | - |
dc.subject.MESH | T-Lymphocytes, Cytotoxic/metabolism | - |
dc.subject.MESH | T-Lymphocytes, Cytotoxic/pathology | - |
dc.subject.MESH | Transplantation, Homologous/adverse effects | - |
dc.subject.MESH | fas Receptor/biosynthesis* | - |
dc.subject.MESH | fas Receptor/genetics | - |
dc.title | Difference in the expression of Fas/Fas-ligand and the lymphocyte subset reconstitution according to the occurrence of acute GVHD | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | S Lee | - |
dc.contributor.googleauthor | SY Chong | - |
dc.contributor.googleauthor | JW Lee | - |
dc.contributor.googleauthor | SC Kim | - |
dc.contributor.googleauthor | YH Min | - |
dc.contributor.googleauthor | JS Hahn | - |
dc.contributor.googleauthor | YW Ko | - |
dc.identifier.doi | 10.1038/sj.bmt.1700986 | - |
dc.contributor.localId | A01407 | - |
dc.relation.journalcode | J00383 | - |
dc.identifier.eissn | 1476-5365 | - |
dc.identifier.pmid | 9404931 | - |
dc.contributor.alternativeName | Min, Yoo Hong | - |
dc.contributor.affiliatedAuthor | 민유홍 | - |
dc.citation.volume | 20 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 883 | - |
dc.citation.endPage | 888 | - |
dc.identifier.bibliographicCitation | BONE MARROW TRANSPLANTATION, Vol.20(10) : 883-888, 1997 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.