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Difference in the expression of Fas/Fas-ligand and the lymphocyte subset reconstitution according to the occurrence of acute GVHD

DC Field Value Language
dc.contributor.author민유홍-
dc.date.accessioned2020-07-03T17:05:52Z-
dc.date.available2020-07-03T17:05:52Z-
dc.date.issued1997-
dc.identifier.issn0268-3369-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/177269-
dc.description.abstractAcute graft-versus-host disease (aGVHD) remains a major barrier to a wider application of allogeneic bone marrow transplantation (BMT). Although this complication is mainly dependent on donor-derived T lymphocytes, very little information is available concerning the mechanism of lethality. In this study, we investigated both the expression of Fas/Fas-ligand (FasL) and lymphocyte subset reconstitution in patients who underwent HLA-matched related allogeneic BMT (n = 16) and normal donors (n = 10), and several distinct features were observed. First, the reconstitutions of CD3+ and CD56+ cells were different between the aGVHD+ and aGVHD- group. In particular, the percentage of CD3-CD56+ cells was significantly decreased in patients with aGVHD (P < 0.01). Second, the expansion of CD8+ (P = 0.01) and CD8+ CD28- T cells (P = 0.03) was a characteristic finding in patients with aGVHD. Finally, we found that the percentages of Fas+CD8+, Fas+HLA-DR+ and FasL+ CD8+ cells were significantly increased. Fas antigen was highly coexpressed on most of the lymphocyte subsets, especially on CD8+ cells (P < 0.01), and also, significantly higher coexpression of FasL on CD8+ cells was found in patients with aGVHD (P < 0.01). In summary, an increase in the percentage of CD8+ cells which express Fas and its ligand in patients with aGVHD after BMT points to a possible role for the Fas/FasL pathway in the effector phase of aGVHD.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfBONE MARROW TRANSPLANTATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAcute Disease-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHBone Marrow Transplantation/adverse effects-
dc.subject.MESHCD8-Positive T-Lymphocytes/immunology-
dc.subject.MESHCD8-Positive T-Lymphocytes/metabolism-
dc.subject.MESHCD8-Positive T-Lymphocytes/pathology*-
dc.subject.MESHFas Ligand Protein-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHGraft Survival-
dc.subject.MESHGraft vs Host Disease/blood-
dc.subject.MESHGraft vs Host Disease/immunology-
dc.subject.MESHGraft vs Host Disease/pathology*-
dc.subject.MESHHumans-
dc.subject.MESHImmunophenotyping-
dc.subject.MESHLeukemia/therapy-
dc.subject.MESHLeukocyte Count-
dc.subject.MESHLymphocyte Count-
dc.subject.MESHMale-
dc.subject.MESHMembrane Glycoproteins/biosynthesis*-
dc.subject.MESHMembrane Glycoproteins/genetics-
dc.subject.MESHT-Lymphocyte Subsets/immunology-
dc.subject.MESHT-Lymphocyte Subsets/metabolism-
dc.subject.MESHT-Lymphocyte Subsets/pathology*-
dc.subject.MESHT-Lymphocytes, Cytotoxic/immunology-
dc.subject.MESHT-Lymphocytes, Cytotoxic/metabolism-
dc.subject.MESHT-Lymphocytes, Cytotoxic/pathology-
dc.subject.MESHTransplantation, Homologous/adverse effects-
dc.subject.MESHfas Receptor/biosynthesis*-
dc.subject.MESHfas Receptor/genetics-
dc.titleDifference in the expression of Fas/Fas-ligand and the lymphocyte subset reconstitution according to the occurrence of acute GVHD-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorS Lee-
dc.contributor.googleauthorSY Chong-
dc.contributor.googleauthorJW Lee-
dc.contributor.googleauthorSC Kim-
dc.contributor.googleauthorYH Min-
dc.contributor.googleauthorJS Hahn-
dc.contributor.googleauthorYW Ko-
dc.identifier.doi10.1038/sj.bmt.1700986-
dc.contributor.localIdA01407-
dc.relation.journalcodeJ00383-
dc.identifier.eissn1476-5365-
dc.identifier.pmid9404931-
dc.contributor.alternativeNameMin, Yoo Hong-
dc.contributor.affiliatedAuthor민유홍-
dc.citation.volume20-
dc.citation.number10-
dc.citation.startPage883-
dc.citation.endPage888-
dc.identifier.bibliographicCitationBONE MARROW TRANSPLANTATION, Vol.20(10) : 883-888, 1997-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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