호흡기 알레르기 환자에서 Phadiatop과 혈청 총 IgE 측정의 아토피 선별 효과 비교

Abstract

background: Phadiatop test has been introduced as a single test for screening the atopics who were sensitized to common inhalant allergens. Material and method: We compared the clinical efficiency of Phadiatop test and total IgE level for defining presence of atopy in 136 asthmatic subjects. The presence of atopy was defined by skin prick test done with 10 common inhalant allergens. More than 2+ skin reactivity was defined as having atopy. Phadiatop test and total IgE level in serum were measured using Pharmacia CAP systems. Result: 109 out of 136 subjects had more than 2+ skin reactivity to at least one allergen and another 27 subjects had 1+ or negative skin reactivity to allergens. The performance characteristics of Phadiatop test for screening atopy was superior than total IgE level, with sensitivity(91.7% vs. 82.6%), positive predictive value(94.3% vs. 86.5%) and concordance rate(89.0 % vs. 75.7% ). Specificity and negative predictive value of the Phadistop test were acceptable and higher than that of total IgE level. Conclusion: These results suggested that Ph adiatop may be simple and useful for screening atopic status in Korean asthmatic subjects.