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급성심근경색증 환자의 혈전용해치료에서 Double Bolus Urokinase와 Front-Loaded Alteplasem요법의 전향적 무작위 비교연구

DC Field Value Language
dc.contributor.author장양수-
dc.contributor.author조승연-
dc.contributor.author조승연-
dc.date.accessioned2020-07-02T17:50:34Z-
dc.date.available2020-07-02T17:50:34Z-
dc.date.issued1998-
dc.identifier.issn1738-5520-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/177070-
dc.description.abstractBackground : This study was performed to compare double bolus urokinase (UK) regimen with front-loaded alteplase regimen for acute myocardial infarction (AMI). Methods : In 26 hospitals, 618 patients with AMI within 6 hours after onset of pain were randomized to receive double bolus UK (UK 1.5 million units intravenous bolus injection, followed by UK 20,000 units /kg intravenous bolus injection 30 minutes after the first dose (up to 1.5 million units) or front-loaded alteplase. Coronary angiography was performed 90 min (N= 200) and/or 7 days (N=303) after thrombolytic therapy. The primary end point was a composite outcome of death, nonfatal reinfarction and nonfatal stroke within 30 days. There were no differences in baseline clinical characteristics. Results : TIMI grade 3 antegrade flow of infarct-related artery at 90 minutes was achieved after treatment with double bolus UK (69.9 %, 79/113) or front-loaded alteplase (67.8 %, 59/87) (p=NS). Angiographic patency at 7 days after thrombolytic therapy was also similar in both groups (81.7 % vs 77.8%). There was no significant difference in 30-day mortality between both groups (4.6 %, 16/350 vs 4.4 %, 12/268 p=NS). The rates of major hemorrhagic strokes was 0.3 % (1/350) in UK group and 1.1 % (3/268) in alteplase group (p=NS). No difference was observed in the rate ofreinfarction between both groups (3.1 %,11/350 vs 3. 4 %, 9/268 , p=NS). A composite outcome was also similar in both groups (8.0 % vs 8.9 %, p=NS ). Conclusions : Double bolus urokinase is an easy, safe and effective thrombolytic regimen with comparable results to standard front-loaded alteplase in the treatment of acute myocardial infarction.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한심장학회-
dc.relation.isPartOfKorean Circulation Journal (순환기)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title급성심근경색증 환자의 혈전용해치료에서 Double Bolus Urokinase와 Front-Loaded Alteplasem요법의 전향적 무작위 비교연구-
dc.title.alternativeA Randomized Comparison of Double Bolus Urokinase versus Front-Loaded Alteplase Regimen for Acute Myocardial Infarction-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorTIMIKO (Thrombolysis in Myocardial Infarction in Korea) 연구회-
dc.contributor.localIdA03448-
dc.contributor.localIdA03844-
dc.contributor.localIdA03844-
dc.contributor.localIdA03844-
dc.contributor.localIdA03844-
dc.relation.journalcodeJ01953-
dc.identifier.eissn1738-5555-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.affiliatedAuthor장양수-
dc.contributor.affiliatedAuthor조승연-
dc.contributor.affiliatedAuthor조승연-
dc.contributor.affiliatedAuthor조승연-
dc.contributor.affiliatedAuthor조승연-
dc.citation.volume28-
dc.citation.number10-
dc.citation.startPage1664-
dc.citation.endPage1669-
dc.identifier.bibliographicCitationKorean Circulation Journal (순환기), Vol.28(10) : 1664-1669, 1998-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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