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Cefatrizine과 clavulanic acid 병합제의 extended-spectrum β-lactamase 생산균에 대한 항균력의 상승작용
DC Field | Value | Language |
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dc.contributor.author | 이경원 | - |
dc.date.accessioned | 2020-07-02T17:46:08Z | - |
dc.date.available | 2020-07-02T17:46:08Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 1225-7850 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177031 | - |
dc.description.abstract | Background : The purpose of this study was to determine the synergistic activity of cefatrizme (CTRZ) combined with clavulanic acid (CV) against extended-spectrum β-lactamase (ESBL) producing strains. Methods : Minimum inhibitory concentration was deterinined by the standard agar dilution method as recommended by the Japan Society of Chemotherapy. CTRZ/CV was evaluated for in vivo efficacy in a variety of experimental intra-peritoneal infections as well as in localized kidney and lung infections in mice. Results : The addition of 0.012 ㎍/mL of CV markedly increased the in vitro antibacterial activity of CTRZ against β-lactamase-producmg strains including ESBL-producing strains and the most effective combination ratio was shown to be between 8:1 and 2:l. The in uivo efficacy of CTRZ and CV in combination was determined using experimental intraperitoneal infections in mice with ESBL-producing Exherichia coli EB13 and Klebsiella pneumoniae EB40 and the inost effective combination ratio was shown to be between 2:1 and 1:2. CTRZ/CV at a ratio of 2:1 showed baetericldal activity against β-lactamase-producing strains including ESBL-producing strains and the therapeutic efficacy of CTRZ/CV against intraperitoneal infection in mice with E. colz EB13, K. pneumoniae EB40 and Proteus vulgaris 5 was superior to that of CTRZ. in respiratory tract infection in mce due to K. pneumoniae EB40, CTRZ/CV at a ratio of 2:1 was more effective than CTRZ and also more efficacious than CTRZ in urinary tract infection in mice due to E. coli EB13. Conclusion : CTRZ/CV combination at a ratio of 2:l is a useful drug for the treatment of infection caused by β-lactamase-producing strains including ESBL-producing strains. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한화학요법학회 | - |
dc.relation.isPartOf | Journal of the Korean Society for Chemotherapy (대한화학요법학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Cefatrizine과 clavulanic acid 병합제의 extended-spectrum β-lactamase 생산균에 대한 항균력의 상승작용 | - |
dc.title.alternative | Synergistic antibacterial activity of cefatrizine and clavulanic acid combination aganist extended-spectrum beta-lactamase producing strains | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | 김지영 | - |
dc.contributor.googleauthor | 김계원 | - |
dc.contributor.googleauthor | 최성학 | - |
dc.contributor.googleauthor | 김원배 | - |
dc.contributor.googleauthor | 이경원 | - |
dc.contributor.googleauthor | 정윤섭 | - |
dc.contributor.localId | A02649 | - |
dc.relation.journalcode | J01850 | - |
dc.contributor.alternativeName | Lee, Kyungwon | - |
dc.contributor.affiliatedAuthor | 이경원 | - |
dc.citation.volume | 16 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 231 | - |
dc.citation.endPage | 238 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society for Chemotherapy (대한화학요법학회지), Vol.16(3) : 231-238, 1998 | - |
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