Cited 7 times in
E-cadherin expression in thymomas
DC Field | Value | Language |
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dc.contributor.author | 양우익 | - |
dc.contributor.author | 홍순원 | - |
dc.date.accessioned | 2020-07-02T17:34:54Z | - |
dc.date.available | 2020-07-02T17:34:54Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176908 | - |
dc.description.abstract | For the purpose of investigating the pattern of E-cadherin (E-CD) expression in thymomas, 72 cases were immunostained using monoclonal antibody (HECD-1) and microwave-enhanced immunohistochemical method on formalin-fixed, paraffin-embedded tissue sections. The thymomas were classified according to modified Müller-Hermelink classification. The spindle-shaped, medullary type tumor epithelial cells in medullary (3 cases) and composite type (20 cases) thymomas rarely expressed E-CD except in focal areas showing microcystic change observed in 8 cases. Meanwhile, the cohesive epithelioid tumor cells in every case of well-differentiated thymic carcinomas (WDTC) (29 cases) expressed E-CD. The epithelial cells in cortical type (13 cases) expressed stronger E-CD compared with those of organoid type (7 cases). In cases of WDTC admixed with cortical type, we observed increasing expression of E-CD as the tumor epithelium forms cohesive sheets. We could not find any loss of E-CD expression in invasive foci of the 11 cases of high-staged WDTC examined. Since the results of our study show a strong correlation between E-CD expression and epithelioid morphology of the tumor, E-CD seems to play a major role as a morpho-regulatory factor rather than as a suppressor of invasion in organotypic thymomas. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cadherins/analysis* | - |
dc.subject.MESH | Cadherins/immunology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Thymoma/chemistry* | - |
dc.subject.MESH | Thymoma/classification | - |
dc.subject.MESH | Thymoma/pathology | - |
dc.subject.MESH | Thymus Neoplasms/chemistry* | - |
dc.subject.MESH | Thymus Neoplasms/classification | - |
dc.subject.MESH | Thymus Neoplasms/pathology | - |
dc.title | E-cadherin expression in thymomas | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Woo Ick Yang | - |
dc.contributor.googleauthor | Kyung Moo Yang | - |
dc.contributor.googleauthor | Soon Won Hong | - |
dc.contributor.googleauthor | Kil Dong Kim | - |
dc.identifier.doi | 10.3349/ymj.1998.39.1.37 | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A04411 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 9529983 | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | 양우익 | - |
dc.contributor.affiliatedAuthor | 홍순원 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 37 | - |
dc.citation.endPage | 44 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.39(1) : 37-44, 1998 | - |
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