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Induction of apoptosis in colon cancer cells by nonsteroidal anti-inflammatory drugs

DC Field Value Language
dc.contributor.author김원호-
dc.date.accessioned2020-07-02T17:25:11Z-
dc.date.available2020-07-02T17:25:11Z-
dc.date.issued1998-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/176800-
dc.description.abstractEpidemiological studies have demonstrated that nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the incidence of colon cancer. In addition, NSAIDs reduce the number and size of polyps in patients with familial adenomatous polyposis. The mechanisms of the anti-neoplastic effect of NSAIDs are still far from complete understanding, but one possible mechanism is the induction of apoptosis. Several lines of evidence suggest that NSAIDs-induced apoptosis in colon cancer cells are mediated through the cyclooxygenase (COX)-independent pathway. In this study we explored the mechanism of NSAIDs-induced apoptosis in the colon cancer cell line, HT-29. We confirmed that NSAIDs induce apoptosis in HT-29 cells irrespective of their COX-selectivity. Indomethacin enhanced the expression of p21waf-1 in HT-29 cells. However the expression of apoptosis-related genes such as Fas, bcl-2 and bax was not affected by indomethacin. Intra- and extra-cellular calcium chelators, protein tyrosine kinase (PTK) inhibitor, protein kinase A (PKA) inhibitor and protein kinase C (PKC) inhibitors did not influence indomethacin-induced apoptosis in HT-29 cells. We concluded that NSAIDs-induced apoptosis in colon cancer cells may be independent from signals transducted through [Ca++]i, PTK, PKA, PKC or the expression of apoptosis-related genes. In contrast, our results demonstrating the induction of p21waf-1 transcription by NSAIDs suggest the possible association of NSAIDs-induced apoptosis and cell-cycle control in colon cancer cells.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnti-Inflammatory Agents, Non-Steroidal/pharmacology*-
dc.subject.MESHApoptosis/drug effects*-
dc.subject.MESHCalcium/metabolism-
dc.subject.MESHCell Survival/drug effects-
dc.subject.MESHColonic Neoplasms/pathology-
dc.subject.MESHColonic Neoplasms/prevention & control*-
dc.subject.MESHCyclin-Dependent Kinase Inhibitor p21-
dc.subject.MESHCyclins/biosynthesis-
dc.subject.MESHCyclins/genetics-
dc.subject.MESHHT29 Cells-
dc.subject.MESHHumans-
dc.subject.MESHProtein Kinases/physiology-
dc.subject.MESHProto-Oncogene Proteins c-bcl-2/analysis-
dc.subject.MESHRNA, Messenger/analysis-
dc.subject.MESHTumor Suppressor Protein p53/physiology-
dc.titleInduction of apoptosis in colon cancer cells by nonsteroidal anti-inflammatory drugs-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSung Pyo Hong-
dc.contributor.googleauthorSung Ho Ha-
dc.contributor.googleauthorIn Suh Park-
dc.contributor.googleauthorWon Ho Kim-
dc.identifier.doi10.3349/ymj.1998.39.4.287-
dc.contributor.localIdA00774-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid9752793-
dc.contributor.alternativeNameKim, Won Ho-
dc.contributor.affiliatedAuthor김원호-
dc.citation.volume39-
dc.citation.number4-
dc.citation.startPage287-
dc.citation.endPage295-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.39(4) : 287-295, 1998-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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